Evidence map›Paper›PMID 34900340›Full record

ArticleFuture science OA2022

Analysis of somatic copy number alterations in biliary tract carcinoma using a single nucleotide polymorphism array.

Yoshihiro Shioi, Mitsumasa Osakabe, Naoki Yanagawa, Hiroyuki Nitta, Akira Sasaki, Tamotsu Sugai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Future science OA, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yoshihiro ShioiDepartment of Molecular Diagnostic Pathology, School of Medicine, Iwate Medical University, 2-1-1, Shiwagun, Yahabachou, 0283695, Japan.ORCID https://orcid.org/0000-0001-9666-5098
Mitsumasa OsakabeDepartment of Molecular Diagnostic Pathology, School of Medicine, Iwate Medical University, 2-1-1, Shiwagun, Yahabachou, 0283695, Japan.
Naoki YanagawaDepartment of Molecular Diagnostic Pathology, School of Medicine, Iwate Medical University, 2-1-1, Shiwagun, Yahabachou, 0283695, Japan.ORCID https://orcid.org/0000-0002-0818-7151
Hiroyuki NittaDepartment of Surgery, School of Medicine, Iwate Medical University, 2-1-1, Shiwagun, Yahabachou, 0283695, Japan.
Akira SasakiDepartment of Surgery, School of Medicine, Iwate Medical University, 2-1-1, Shiwagun, Yahabachou, 0283695, Japan.
Tamotsu SugaiDepartment of Molecular Diagnostic Pathology, School of Medicine, Iwate Medical University, 2-1-1, Shiwagun, Yahabachou, 0283695, Japan.ORCID https://orcid.org/0000-0002-4896-3557
Iwate Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimBiliary tract carcinoma (BTC), including gall bladder carcinoma (GBC) and biliary duct carcinoma (BDC), has a poor prognosis. Comprehensive genomic profiling has important roles in evaluation of the carcinogenesis of BTC. MATERIALS &

methodsWe examined somatic copy number alterations (SCNAs) using a single nucleotide polymorphism array system to analyze 36 BTC samples (11 GBCs and 25 BDCs).

resultsIn hierarchical cluster analysis, two clusters were identified (subgroup 1 with low SCNAs and subgroup 2 with high SCNAs). GBC was predominant in subgroup 1, whereas BDC was predominant in subgroup 2, suggesting that GBC and BDC had different genetic backgrounds in terms of SCNAs.

conclusionThese findings could be helpful for establishing the molecular carcinogenesis of BTCs.

Indexed as

bile duct cancerbiliary tract carcinomacarcinogenesiscluster analysiscrypt isolation methodgall bladder cancermolecular alterationprognosissingle nucleotide polymorphism arraysomatic copy number alteration

Identifiers

PMID34900340
PMCPMC8656348
OpenAlexW3214292246

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.