Evidence map›Paper›PMID 34900058›Full record

ArticleArchives of medical science : AMS2021

Genetic polymorphism of

Luz María Torres Espindola, Manuel De JesÚs Castillejos López, Armando De Uña Flores, Liliana Rivera Espinosa, Julio Granados, Juan Luis Chávez Pacheco, Martín Pérez García, Ma Teresa Ramos Cervantes, Vilma Carolina Bekker Méndez, Susana Hernández Doño and 1 more

Open access · goldAbstract read
In one paragraph

Article in Archives of medical science : AMS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Sex and Age Influence on Association ofDiagnostics (Basel, Switzerland) · 2022
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Luz María Torres EspindolaNational Institute of Pediatrics, Mexico City, Mexico.
Manuel De JesÚs Castillejos LópezNational Institute of Respiratory Diseases, Mexico City, Mexico.
Armando De Uña FloresNational Institute of Pediatrics, Mexico City, Mexico.
Liliana Rivera EspinosaNational Institute of Pediatrics, Mexico City, Mexico.
Julio GranadosNational Institute of Medical Sciences and Nutrition Salvador Zubirán, Mexico City, Mexico.
Juan Luis Chávez PachecoNational Institute of Pediatrics, Mexico City, Mexico.
Martín Pérez GarcíaNational Institute of Pediatrics, Mexico City, Mexico.
Ma Teresa Ramos CervantesGeneral Hospital Dr. Gaudencio González Garza, National Medical Center "La Raza", Mexico City, Mexico.
Vilma Carolina Bekker MéndezHospital of CMN Infectology "La Raza" IMSS, Mexico City, Mexico.
Susana Hernández DoñoNational Institute of Medical Sciences and Nutrition Salvador Zubirán, Mexico City, Mexico.
Daniela Ruíz GómezNational Institute of Medical Sciences and Nutrition Salvador Zubirán, Mexico City, Mexico.
Tecnológico Nacional de México · MXInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán · MXCentro Médico Nacional La Raza · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe CYP450 complex participates in the metabolism of ifosfamide, an antineoplastic drug used to treat solid tumors. MATERIAL AND

methods148 DNA samples from children were analyzed. Genotyping was performed by real-time PCR with TaqMan probes and ifosfamide levels were determined in dried blood drop by UPLCMS/MS.

resultsIfosfamide levels increased according to the genotype, and patients with the variant rs1799853 in

conclusionsPolymorphisms in

Indexed as

CYP450embryonic solid tumorspolymorphismsresponse

Identifiers

PMID34900058
PMCPMC8641500
OpenAlexW2969715079

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.