Evidence map›Paper›PMID 34900030›Full record

ArticleDisease markers2021

Protective Effect of Fasudil on Hydrogen Peroxide-Induced Oxidative Stress Injury of H9C2 Cardiomyocytes.

Yu Zhang, Shanxin Liu, Xiaochun Li, Jian Ye

Open access · hybridAbstract read
In one paragraph

Article in Disease markers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Yu ZhangDepartment of Cardiology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.ORCID https://orcid.org/0000-0002-6688-5927
Shanxin LiuDepartment of Cardiology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.
Xiaochun LiDepartment of Infectious Diseases, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
Jian YeDepartment of Cardiology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
Second Affiliated Hospital of Zhejiang University · CNAffiliated Hospital of Hangzhou Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveOxidative damage is a pathological factor that causes cardiovascular damage in the clinic and is increasingly serious. This study focused on the effect of fasudil on H MATERIALS AND

methodsH9C2 cardiomyocytes were cultured in vitro and divided into three groups: control group (Con group), H

resultsOur results showed that after H

conclusionsFasudil can inhibit the Rho/ROCK signaling pathway induced by H

Indexed as

1-(5-Isoquinolinesulfonyl)-2-MethylpiperazineAnimalsAntioxidantsCell LineEnzyme-Linked Immunosorbent AssayHydrogen PeroxideMyocytes, CardiacOxidative StressProtein Kinase InhibitorsRatsSignal Transduction1-(5-Isoquinolinesulfonyl)-2-MethylpiperazineAntioxidantsfasudilHydrogen PeroxideProtein Kinase Inhibitors

Identifiers

PMID34900030
PMCPMC8654537
OpenAlexW3216948051

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.