Evidence map›Paper›PMID 34899963›Full record

ArticleComputational and mathematical methods in medicine2021

Shared Molecular Mechanisms between Atherosclerosis and Periodontitis by Analyzing the Transcriptomic Alterations of Peripheral Blood Monocytes.

Wanchen Ning, Yihong Ma, Simin Li, Xin Wang, Hongying Pan, Chenxuan Wei, Shaochuan Zhang, Dongying Bai, Xiangqiong Liu, Yupei Deng and 10 more

RetractedOpen access · hybridAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and mathematical methods in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
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  4. Article
  5. Review
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  7. Review
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 11 institutions in 6 countries.

Wanchen NingStomatological Hospital, Southern Medical University, Guangzhou 510280, China.ORCID https://orcid.org/0000-0003-1075-997X
Yihong MaDepartment of Neurology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.ORCID https://orcid.org/0000-0001-8710-4707
Simin LiStomatological Hospital, Southern Medical University, Guangzhou 510280, China.ORCID https://orcid.org/0000-0003-4011-0282
Xin WangDepartment of Neurology, First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.ORCID https://orcid.org/0000-0001-6998-7040
Hongying PanSchool of Dentistry, University of Michigan, 1011 N University Ave, Ann Arbor, MI 48109, USA.ORCID https://orcid.org/0000-0003-1270-6636
Chenxuan WeiSchool of Dentistry, University of Michigan, 1011 N University Ave, Ann Arbor, MI 48109, USA.ORCID https://orcid.org/0000-0003-0747-8114
Shaochuan ZhangDivision of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID https://orcid.org/0000-0002-4853-4525
Dongying BaiCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, China.ORCID https://orcid.org/0000-0002-9296-9235
Xiangqiong LiuLaboratory of Molecular Cell Biology, Beijing Tibetan Hospital, China Tibetology Research Center, 218 Anwaixiaoguanbeili Street, Chaoyang, Beijing 100029, China.ORCID https://orcid.org/0000-0001-8942-9505
Yupei DengLaboratory of Molecular Cell Biology, Beijing Tibetan Hospital, China Tibetology Research Center, 218 Anwaixiaoguanbeili Street, Chaoyang, Beijing 100029, China.ORCID https://orcid.org/0000-0002-6083-0087
Aneesha AcharyaDr D Y Patil Dental College and Hospital, Dr D Y Patil Vidyapeeth, Pimpri, Pune, India.ORCID https://orcid.org/0000-0002-9319-6780
George PelekosFaculty of Dentistry, University of Hong Kong, Hong KongChina.ORCID https://orcid.org/0000-0003-1917-1988
Vuk SavkovicDepartment of Cranio Maxillofacial Surgery, University Clinic Leipzig, Liebigstr. 12, 04103 Leipzig, Germany.ORCID https://orcid.org/0000-0003-3832-4281
Hanluo LiDepartment of Cranio Maxillofacial Surgery, University Clinic Leipzig, Liebigstr. 12, 04103 Leipzig, Germany.ORCID https://orcid.org/0000-0001-9109-2972
Sebastian GausDepartment of Cranio Maxillofacial Surgery, University Clinic Leipzig, Liebigstr. 12, 04103 Leipzig, Germany.ORCID https://orcid.org/0000-0001-8231-9610
Rainer HaakDepartment of Cariology, Endodontology and Periodontology, University of Leipzig, 04103 Leipzig, Germany.ORCID https://orcid.org/0000-0002-3716-4231
Gerhard SchmalzDepartment of Cariology, Endodontology and Periodontology, University of Leipzig, 04103 Leipzig, Germany.ORCID https://orcid.org/0000-0002-6602-377X
Dirk ZiebolzDepartment of Cariology, Endodontology and Periodontology, University of Leipzig, 04103 Leipzig, Germany.ORCID https://orcid.org/0000-0002-9810-2368
Yanbo MaCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, China.ORCID https://orcid.org/0000-0002-2298-1124
Yuzhen XuDepartment of Rehabilitation, The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong Province 271000, China.ORCID https://orcid.org/0000-0002-1289-3438
Henan University of Science and Technology · CNLeipzig University · DEUniversity Hospital Leipzig · DEChina Tibetology Research Center · CNSouthern Medical University · CNUniversity of Michigan · USAffiliated Hospital of Taishan Medical University · CNDr. D.Y. Patil Vidyapeeth, Pune · INHarbin Medical University · CNNagoya University · JPUniversity of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study investigated the nature of shared transcriptomic alterations in PBMs from periodontitis and atherosclerosis to unravel molecular mechanisms underpinning their association.

methodsGene expression data from PBMs from patients with periodontitis and those with atherosclerosis were each downloaded from the GEO database. Differentially expressed genes (DEGs) in periodontitis and atherosclerosis were identified through differential gene expression analysis. The disease-related known genes related to periodontitis and atherosclerosis each were downloaded from the DisGeNET database. A Venn diagram was constructed to identify crosstalk genes from four categories: DEGs expressed in periodontitis, periodontitis-related known genes, DEGs expressed in atherosclerosis, and atherosclerosis-related known genes. A weighted gene coexpression network analysis (WGCNA) was performed to identify significant coexpression modules, and then, coexpressed gene interaction networks belonging to each significant module were constructed to identify the core crosstalk genes.

resultsFunctional enrichment analysis of significant modules obtained by WGCNA analysis showed that several pathways might play the critical crosstalk role in linking both diseases, including bacterial invasion of epithelial cells, platelet activation, and Mitogen-Activated Protein Kinases (MAPK) signaling. By constructing the gene interaction network of significant modules, the core crosstalk genes in each module were identified and included: for GSE23746 dataset, RASGRP2 in the blue module and VAMP7 and SNX3 in the green module, as well as HMGB1 and SUMO1 in the turquoise module were identified; for GSE61490 dataset, SEC61G, PSMB2, SELPLG, and FIBP in the turquoise module were identified.

conclusionExploration of available transcriptomic datasets revealed core crosstalk genes (RASGRP2, VAMP7, SNX3, HMGB1, SUMO1, SEC61G, PSMB2, SELPLG, and FIBP) and significant pathways (bacterial invasion of epithelial cells, platelet activation, and MAPK signaling) as top candidate molecular linkage mechanisms between atherosclerosis and periodontitis.

Indexed as

TranscriptomeAtherosclerosisCarrier ProteinsComputational BiologyDatabases, GeneticGene Expression ProfilingGene Regulatory NetworksGenetic MarkersGuanine Nucleotide Exchange FactorsHMGB1 ProteinHumansMembrane GlycoproteinsMembrane ProteinsMonocytesPeriodontitisProteasome Endopeptidase ComplexCarrier ProteinsFIBP protein, humanGenetic MarkersGuanine Nucleotide Exchange FactorsHMGB1 ProteinHMGB1 protein, humanMembrane GlycoproteinsMembrane ProteinsProteasome Endopeptidase ComplexP-selectin ligand proteinPSMB2 protein, humanRASGRP2 protein, humanR-SNARE ProteinsSEC61G protein, humanSEC Translocation ChannelsSUMO-1 ProteinSUMO1 protein, humanVAMP7 protein, human

Identifiers

PMID34899963
PMCPMC8664523
OpenAlexW4200619744

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.