Evidence map›Paper›PMID 34899822›Full record

ArticleFrontiers in genetics2021

POLR2A Promotes the Proliferation of Gastric Cancer Cells by Advancing the Overall Cell Cycle Progression.

Qiuyu Jiang, Jinyuan Zhang, Fang Li, Xiaoping Ma, Fei Wu, Jiyu Miao, Qian Li, Xiaofei Wang, Ruifang Sun, Yang Yang and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
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  6. Krüppel-Like Factor 6 Induces RNA Polymerase II Subunit RPB1 to Promote Kidney Injury.Journal of the American Society of Nephrology : JASN · 2025
    Article
  7. USP10 Inhibits Ferroptosis via Deubiquinating POLR2A in Head and Neck Squamous Cell Carcinoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  8. Article
  9. Transcriptional rewiring in cancer driven byFrontiers in pharmacology · 2025
    Review
  10. Article
  11. ANKK1 Is a Wnt/PCP Scaffold Protein for Neural F-ACTIN Assembly.International journal of molecular sciences · 2024
    Article
  12. Article
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  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Qiuyu JiangInstitute of Genetics and Development Biology, Translational Medcine Institute, Xi'an Jiaotong University, Xi'an, China.
Jinyuan ZhangInstitute of Genetics and Development Biology, Translational Medcine Institute, Xi'an Jiaotong University, Xi'an, China.
Fang LiInstitute of Genetics and Development Biology, Translational Medcine Institute, Xi'an Jiaotong University, Xi'an, China.
Xiaoping MaInstitute of Genetics and Development Biology, Translational Medcine Institute, Xi'an Jiaotong University, Xi'an, China.
Fei WuDepartment of Oncology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Jiyu MiaoDepartment of Hematology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Qian LiDepartment of Gastroenterology, The First Affiliated Hospital of Xi'an Medical University, Xi'an, China.
Xiaofei WangBiomedical Experiment Center, Xian Jiaotong University, Xi'an, China.
Ruifang SunInstitute of Genetics and Development Biology, Translational Medcine Institute, Xi'an Jiaotong University, Xi'an, China.
Yang YangDepartment of Toxicology and Sanitary Analysis, School of Public Health, Xi'an Jiaotong University, Xi'an, China.
Lingyu ZhaoInstitute of Genetics and Development Biology, Translational Medcine Institute, Xi'an Jiaotong University, Xi'an, China.
Chen HuangInstitute of Genetics and Development Biology, Translational Medcine Institute, Xi'an Jiaotong University, Xi'an, China.
Xi'an Jiaotong University · CNSecond Affiliated Hospital of Xi'an Jiaotong University · CNXi'an Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RNA polymerase II subunit A (POLR2A) is the largest subunit encoding RNA polymerase II and closely related to cancer progression. However, the biological role and underlying molecular mechanism of POLR2A in gastric cancer (GC) are still unclear. Our study demonstrated that POLR2A was highly expressed in GC tissue and promoted the proliferation of GC

Indexed as

cell cyclegastric canceroncogenePolR2atranscriptional regulation

Identifiers

PMID34899822
PMCPMC8655910
OpenAlexW3215813247

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.