Evidence map›Paper›PMID 34899746›Full record

ReviewFrontiers in immunology2021

Microfluidic Systems to Study Neutrophil Forward and Reverse Migration.

Kehinde Adebayo Babatunde, Jose M Ayuso, Sheena C Kerr, Anna Huttenlocher, David J Beebe

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Leveraging Microphysiological Systems to Facilitate Neutrophil-Based Cancer Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  2. Frontiers in immunology · 2026
    Article
  3. Beyond Killing: The Overlooked Contribution of Neutrophils to Tissue Repair.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kehinde Adebayo BabatundeDepartment of Pathology & Laboratory Medicine, University of Wisconsin, Madison, WI, United States.
Jose M AyusoDepartment of Pathology & Laboratory Medicine, University of Wisconsin, Madison, WI, United States.
Sheena C KerrDepartment of Pathology & Laboratory Medicine, University of Wisconsin, Madison, WI, United States.
Anna HuttenlocherDepartments of Pediatrics and Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, United States.
David J BeebeDepartment of Pathology & Laboratory Medicine, University of Wisconsin, Madison, WI, United States.
University of Wisconsin–Madison · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
Microscale models of inflammation and its resolutionR01AI134749 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI BEEBE, DAVID J, HUTTENLOCHER, ANNA · 2018 to 2022
$3.8M
A multiplexed micro scale assay for real time analysis of pediatric immune cell functionU24AI152177 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI BEEBE, DAVID J, KERR, SHEENA CATHERINE · 2020 to 2024
$1.8M
NCI NIH HHS P30 CA014520NIAID NIH HHS R01 AI134749NIAID NIH HHS U24 AI152177
6 · The paper itself

Abstract

During infection, neutrophils are the most abundantly recruited innate immune cells at sites of infection, playing critical roles in the elimination of local infection and healing of the injury. Neutrophils are considered to be short-lived effector cells that undergo cell death at infection sites and in damaged tissues. However, recent

Indexed as

Cell CommunicationChemotaxis, LeukocyteLab-On-A-Chip DevicesAnimalsCells, CulturedHost-Pathogen InteractionsHumansInflammation MediatorsMicrofluidic Analytical TechniquesNeutrophilsPhenotypeSignal TransductionInflammation Mediatorsforward migrationmicrofluidicmigrationneutrophilsreverse migration

Identifiers

PMID34899746
PMCPMC8653704
OpenAlexW3215259393

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.