Evidence map›Paper›PMID 34899728›Full record

ArticleFrontiers in immunology2021

Quercetin Preserves Oral Cavity Health by Mitigating Inflammation and Microbial Dysbiosis.

Erin C Mooney, Sara E Holden, Xia-Juan Xia, Yajie Li, Min Jiang, Camille N Banson, Bin Zhu, Sinem Esra Sahingur

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Erin C MooneyDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Sara E HoldenDepartment of Periodontics, School of Dentistry, Virginia Commonwealth University, Richmond, VA, United States.
Xia-Juan XiaDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Yajie LiDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Min JiangDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Camille N BansonDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Bin ZhuDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, United States.
Sinem Esra SahingurDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, United States.
University of Pennsylvania · USVirginia Commonwealth University · US

Funding

Microbial Nucleic Acid Sensing in PeriodontitisR01DE025037 · NIDCR · VIRGINIA COMMONWEALTH UNIVERSITY · PI SAHINGUR, SINEM ESRA · 2015 to 2019
$1.9M
Endogenous Regulators of Inflammation in Periodontal Tissue HomeostasisR01DE027374 · NIDCR · VIRGINIA COMMONWEALTH UNIVERSITY · PI SAHINGUR, SINEM ESRA · 2018 to 2022
$1.9M
NIDCR NIH HHS R01 DE025037NIDCR NIH HHS R01 DE027374
6 · The paper itself

Abstract

Failure to attenuate inflammation coupled with consequent microbiota changes drives the development of bone-destructive periodontitis. Quercetin, a plant-derived polyphenolic flavonoid, has been linked with health benefits in both humans and animals. Using a systematic approach, we investigated the effect of orally delivered Quercetin on host inflammatory response, oral microbial composition and periodontal disease phenotype.

Indexed as

Alveolar Bone LossAnimalsAnti-Inflammatory AgentsAntioxidantsBiomarkersCell LineCytokinesDysbiosisGingivaHumansImmunohistochemistryInflammation MediatorsMacrophagesMaleMiceMicrobiotaAnti-Inflammatory AgentsAntioxidantsBiomarkersCytokinesInflammation MediatorsQuercetinA20flavonoidsIL-6microbiomeNF-κBperiodontal diseasesTNFtoll-like receptor (TLR)

Identifiers

PMID34899728
PMCPMC8663773
OpenAlexW3216771927

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.