Evidence map›Paper›PMID 34899724›Full record

ArticleFrontiers in immunology2021

Effectiveness of Regdanvimab Treatment in High-Risk COVID-19 Patients to Prevent Progression to Severe Disease.

Ji Yeon Lee, Jee Young Lee, Jae-Hoon Ko, Miri Hyun, Hyun Ah Kim, Seongcheol Cho, Yong Dae Lee, Junghoon Song, Seunghwan Shin, Kyong Ran Peck

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 33 citations in OpenAlex.

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  13. Systemic sclerosis in the time of COVID-19.The Lancet. Rheumatology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Ji Yeon LeeDivision of Infectious Diseases, Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, South Korea.
Jee Young LeeDepartment of Internal Medicine, Seoul Red Cross Hospital, Seoul, South Korea.
Jae-Hoon KoDivision of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Miri HyunDivision of Infectious Diseases, Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, South Korea.
Hyun Ah KimDivision of Infectious Diseases, Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, South Korea.
Seongcheol ChoDepartment of Internal Medicine, Seoul Red Cross Hospital, Seoul, South Korea.
Yong Dae LeeDepartment of Internal Medicine, Seoul Red Cross Hospital, Seoul, South Korea.
Junghoon SongDepartment of Internal Medicine, Seoul Red Cross Hospital, Seoul, South Korea.
Seunghwan ShinDepartment of Internal Medicine, Seoul Red Cross Hospital, Seoul, South Korea.
Kyong Ran PeckDivision of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Korean Red Cross · KRKeimyung University · KRSamsung Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate clinical effectiveness of regdanvimab, a monoclonal antibody agent for treating coronavirus 2019 (COVID-19). Methods: A retrospective cohort study was conducted at two general hospitals during the study period of December 2020 to May 2021. Mild COVID-19 patients with risk factors for disease progression admitted to the hospitals within seven days of symptom onset were enrolled and followed until discharge or referral. Multivariate analyses for disease progression were conducted in the total and propensity score (PS)-matched cohorts. Results: A total of 778 mild COVID-19 patients were included and classified as the regdanvimab (n = 234) and supportive care (n = 544) groups. Significantly fewer patients required O Conclusion: Regdanvimab treatment was associated with a decreased risk of progression to severe disease.

Indexed as

COVID-19 Drug TreatmentAdultAgedAntibodies, Monoclonal, HumanizedAntibodies, NeutralizingCOVID-19Disease ProgressionFemaleHumansImmunoglobulin GMaleMiddle AgedMultivariate AnalysisProgression-Free SurvivalRetrospective StudiesRisk FactorsAntibodies, Monoclonal, HumanizedAntibodies, NeutralizingImmunoglobulin GregdanvimabCOVID-19monoclonal antibodyoutcomeprogressionRegdanvimab

Identifiers

PMID34899724
PMCPMC8657590
OpenAlexW3215399721

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.