Evidence map›Paper›PMID 34899712›Full record

ReviewFrontiers in immunology2021

Type III Interferons: Emerging Roles in Autoimmunity.

Sindhu Manivasagam, Robyn S Klein

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
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  15. Zebrafish (International journal of molecular sciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sindhu ManivasagamCenter for Neuroimmunology & Neuroinfectious Diseases, Washington University School of Medicine, St. Louis, MO, United States.
Robyn S KleinCenter for Neuroimmunology & Neuroinfectious Diseases, Washington University School of Medicine, St. Louis, MO, United States.
Washington University in St. Louis · US

Funding

Neuroprotection and repair during West Nile Virus EncephalitisR01NS052632 · NINDS · WASHINGTON UNIVERSITY · PI KLEIN, ROBYN S. · 2005 to 2020
$5.0M
Research Program Award (R35 Clinical Trial Optional) - Dr. Robyn Klein NINDSR35NS122310 · NINDS · WASHINGTON UNIVERSITY · PI CAIN, MATTHEW D · 2021 to 2024
$3.7M
NEUROPATHOGENESIS OF ZIKA VIRUS INFECTIONSR01NS104471 · NINDS · WASHINGTON UNIVERSITY · PI KLEIN, ROBYN S. · 2018 to 2020
$1.4M
Innate immune mechanisms of virologic control and recovery from flavivirus encephalitisR56AI147623 · NIAID · WASHINGTON UNIVERSITY · PI KLEIN, ROBYN S., SUTHAR, MEHUL SHAMAL · 2020 to 2020
$775k
Astrocyte innate immune mechanisms of post-viral cognitive dysfunctionR01NS116788 · NINDS · WASHINGTON UNIVERSITY · PI KLEIN, ROBYN S. · 2021 to 2021
$394k
TARGETING INTERFERON LAMBDA SIGNALING DURING CENTRAL NERVOUS SYSTEM AUTOIMMUNITYF31NS108629 · NINDS · WASHINGTON UNIVERSITY · PI MANIVASAGAM, SINDHU · 2019 to 2020
$65k
NIAID NIH HHS R56 AI147623NINDS NIH HHS F31 NS108629NINDS NIH HHS R01 NS052632NINDS NIH HHS R01 NS104471NINDS NIH HHS R01 NS116788NINDS NIH HHS R35 NS122310
6 · The paper itself

Abstract

Type III interferons (IFNs) or the lambda IFNs (IFNLs or IFN-λs) are antimicrobial cytokines that play key roles in immune host defense at endothelial and epithelial barriers. IFNLs signal

Indexed as

AnimalsAutoimmune DiseasesAutoimmunityB-LymphocytesDendritic CellsHumansImmunomodulationInterferon LambdaInterferonsMacrophagesReceptors, InterferonSignal TransductionT-LymphocytesInterferon LambdaInterferonsReceptors, Interferonautoimmune diseasesIFNLRinterferon lambdaneuroimmunology and neuropathologyTh1 cells

Identifiers

PMID34899712
PMCPMC8660671
OpenAlexW3216834719

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.