Evidence map›Paper›PMID 34899645›Full record

ArticleFrontiers in microbiology2021

Cell-Extrinsic Priming Increases Permissiveness of CD4+ T Cells to Human Immunodeficiency Virus Infection by Increasing C-C Chemokine Receptor Type 5 Co-receptor Expression and Cellular Activation Status.

Jesper G Pedersen, Johanne H Egedal, Thomas A Packard, Karthiga Thavachelvam, Guorui Xie, Renée Marije van der Sluis, Warner C Greene, Nadia R Roan, Martin R Jakobsen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Jesper G PedersenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Johanne H EgedalDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Thomas A PackardGladstone Institute of Virology, San Francisco, CA, United States.
Karthiga ThavachelvamDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Guorui XieGladstone Institute of Virology, San Francisco, CA, United States.
Renée Marije van der SluisDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Warner C GreeneGladstone Institute of Virology, San Francisco, CA, United States.
Nadia R RoanGladstone Institute of Virology, San Francisco, CA, United States.
Martin R JakobsenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Gladstone Institutes · USAarhus University · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The chemokine receptor CCR5 is expressed on multiple cell types, including macrophages, dendritic cells, and T cells, and is the major co-receptor used during HIV transmission. Using a standard αCD3/CD28

Indexed as

CCR5CD4 T cellhuman immunodeficiency virus (HIV)PD-1priming

Identifiers

PMID34899645
PMCPMC8661899
OpenAlexW3214995083

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.