ReviewFrontiers in endocrinology2021
Appetite Regulation of TLR4-Induced Inflammatory Signaling.
Review in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 51 citations in OpenAlex.
- Intestinal epithelial TLR4 knock out induces sex-specific effects on gut barrier and microbiome in an activity-based anorexia model.Gut microbes · 2026Article
- Attenuated dietary motivation in Wilson's disease correlates with clinical severity.Orphanet journal of rare diseases · 2026Article
- Gut Microbiome Mediates the Causal Link Between Autism Spectrum Disorder and Dietary Preferences: A Mendelian Randomization Study.International journal of molecular sciences · 2026Article
- Sequence-based genome-wide association study reveals genetic and metabolic mechanisms underlying feed efficiency-related traits in beef cattle.Journal of animal science and biotechnology · 2026Article
- Mechanisms of postoperative anorexia in surgical patients: a narrative review.Frontiers in neuroscience · 2026Review
- The Symptom Clusters and Core Symptoms in Patients with Lung Cancer After Surgery: A Longitudinal Network Analysis.Patient preference and adherence · 2026Article
- Identifying the heterogeneity of self-advocacy in Chinese patients with breast cancer using latent profile analysis and symptom networks.Asia-Pacific journal of oncology nursing · 2025Article
- The relationship between oral frailty and cognitive function in elderly patients with chronic diseases: the chain-mediated effect of nutrition status and the inflammatory marker CRP.BMC geriatrics · 2025Article
- Exploring the relationship between residual cholesterol, body mass index, and hypertension risk: a national cohort study.Lipids in health and disease · 2025Observational
- Neonatal Inflammation and Feeding Disorders at 1 Year in Infants With Congenital Gastrointestinal Malformations.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Plant-based dietary indices association with appetite, appetite regulating peptides and gut microbiota in healthy women: a cross-sectional study.European journal of nutrition · 2025Article
- TLR4-dependent neuroinflammation mediates LPS-driven food-reward alterations during high-fat exposure.Journal of neuroinflammation · 2024Article
- Gut microbiota-derived gamma-aminobutyric acid improves host appetite by inhibiting satiety hormone secretion.mSystems · 2024Article
- Article
- Circulating Fatty Acids Associate with Metabolic Changes in Adolescents Living with Obesity.Biomedicines · 2024Article
- Proinflammatory cytokines interleukin-18 and interleukin-6 mediate anorexia induction by trichothecene deoxynivalenol and its congeners.Frontiers in veterinary science · 2024Article
- Quercetin Protects Against Global Cerebral ischemia‒reperfusion Injury by Inhibiting Microglial Activation and Polarization.Journal of inflammation research · 2024Article
- TT Genotype ofNutrients · 2023Article
- Subclinical Reactive Hypoglycemia with Low Glucose Effectiveness-Why We Cannot Stop Snacking despite Gaining Weight.Metabolites · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Appetite is the basis for obtaining food and maintaining normal metabolism. Toll-like receptor 4 (TLR4) is an important receptor expressed in the brain that induces inflammatory signaling after activation. Inflammation is considered to affect the homeostatic and non-homeostatic systems of appetite, which are dominated by hypothalamic and mesolimbic dopamine signaling. Although the pathological features of many types of inflammation are known, their physiological functions in appetite are largely unknown. This review mainly addresses several key issues, including the structures of the homeostatic and non-homeostatic systems. In addition, the mechanism by which TLR4-induced inflammatory signaling contributes to these two systems to regulate appetite is also discussed. This review will provide potential opportunities to develop new therapeutic interventions that control appetite under inflammatory conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.