Evidence map›Paper›PMID 34899308›Full record

ArticleFrontiers in pharmacology2021

Excretion and Residual Concentration Correlations of Salbutamol Between Edible Tissues and Living Samples in Pigs and Goats.

Lei Sun, Minjuan Zhu, Jingfei Shi, Kun Mi, Wenjing Ma, Xiangyue Xu, Hanyu Wang, Yuanhu Pan, Yanfei Tao, Zhenli Liu and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Determination of βMolecules (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Lei SunMOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, Wuhan, China.
Minjuan ZhuMOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, Wuhan, China.
Jingfei ShiMOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, Wuhan, China.
Kun MiMOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, Wuhan, China.
Wenjing MaMOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, Wuhan, China.
Xiangyue XuMOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, Wuhan, China.
Hanyu WangMOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, Wuhan, China.
Yuanhu PanMOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, Wuhan, China.
Yanfei TaoMOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, Wuhan, China.
Zhenli LiuMOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, Wuhan, China.
Lingli HuangMOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, Wuhan, China.
Huazhong Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Illegal use of salbutamol (SAL), a β-adrenergic leanness-enhancing agent, has posed potential threat to human health in China. The excretion and depletion of SAL in pigs and goats were investigated, and the concentration correlations between edible tissues and living samples were analyzed to find out a suitable living sample for pre-slaughter monitoring of SAL in pigs and goats. After a single oral dosage of 1.2 mg/kg SAL, approximately 70% of the dose was excreted by pigs and goats from their excreta. When pigs and goats were supplied feed containing SAL (20 mg/kg) for 14 consecutive days, high concentrations of SAL were observed in the liver and kidneys, and the longest persistence was observed in hair. Unlike pigs, SAL was presented primarily as conjugated SAL in goats. Excellent concentration correlations of SAL were observed between urine and edible tissues both in pigs and goats, and in addition, good correlations also were found between hair and edible tissues in pigs and between feces and edible tissues in goats. Hence, urine and hair could accurately predict SAL concentrations in edible tissues of pigs, whereas feces and urine were satisfactory for predicting SAL concentrations in edible tissues of goats. These data make it possible for pre-slaughter monitoring of SAL residues in the edible tissues of pigs and goats.

Indexed as

depletionexcretiongoatpigpre-slaughter monitoringSAL

Identifiers

PMID34899308
PMCPMC8655863
OpenAlexW3216238907

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.