ArticleFrontiers in cellular neuroscience2021
New Insights and Methods for Recording and Imaging Spontaneous Spreading Depolarizations and Seizure-Like Events in Mouse Hippocampal Slices.
Article in Frontiers in cellular neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- Multifocal Initiation of Spreading Depolarization by Generalized Tonic-Clonic Seizures.International journal of molecular sciences · 2026Article
- Dual role of spreading depolarization in an epileptic focus.Epilepsia · 2026Article
- Spreading depolarization is followed by seizure-like activation of the hippocampus: potential mechanism of migraine-aura triggered seizures.The journal of headache and pain · 2025Article
- Article
- Increasing adult-born neurons protects mice from epilepsy.bioRxiv : the preprint server for biology · 2024Article
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Abstract
Spreading depolarization (SD) is a sudden, large, and synchronous depolarization of principal cells which also involves interneurons and astrocytes. It is followed by depression of neuronal activity, and it slowly propagates across brain regions like cortex or hippocampus. SD is considered to be mechanistically relevant to migraine, epilepsy, and traumatic brain injury (TBI), but there are many questions about its basic neurophysiology and spread. Research into SD in hippocampus using slices is often used to gain insight and SD is usually triggered by a focal stimulus with or without an altered extracellular buffer. Here, we optimize an
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