Evidence map›Paper›PMID 34899170›Full record

ArticleFrontiers in neuroscience2021

Transcutaneous Auricular Vagus Nerve Stimulation (tAVNS) Delivered During Upper Limb Interactive Robotic Training Demonstrates Novel Antagonist Control for Reaching Movements Following Stroke.

Johanna L Chang, Ashley N Coggins, Maira Saul, Alexandra Paget-Blanc, Malgorzata Straka, Jason Wright, Timir Datta-Chaudhuri, Stavros Zanos, Bruce T Volpe

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05943431 (A Randomized, Double-blind Controlled Trial Investigating the Efficacy of Transcutaneous Auricular Vagus Nerve Stimulation), which is not on this map. Cited by 46 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 9 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05943431 naunknown statusnot on this mapstarted 2023, after this paper: background citation

A Randomized, Double-blind Controlled Trial Investigating the Efficacy of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) in Improving Upper Extremity Motor Function in Stroke Patients

TypeinterventionalSponsorQiuyou XieRan2023 to 2025Enrolled150ConditionsUpper Extremity Dysfunction, StrokeArmspaired taVNS, Unpaired taVNS, Sham taVNS
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 9 syntheses or guidelines pooled it, 55 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Johanna L ChangInstitute of Molecular Medicine, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, United States.
Ashley N CogginsInstitute of Molecular Medicine, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, United States.
Maira SaulInstitute of Molecular Medicine, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, United States.
Alexandra Paget-BlancDepartment of Psychiatry, University of Illinois at Chicago, Chicago, IL, United States.
Malgorzata StrakaInstitute for Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Manhasset, NY, United States.
Jason WrightInstitute for Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Manhasset, NY, United States.
Timir Datta-ChaudhuriInstitute for Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Manhasset, NY, United States.
Stavros ZanosInstitute for Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Manhasset, NY, United States.
Bruce T VolpeInstitute of Molecular Medicine, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, United States.
Feinstein Institute for Medical Research · USNorthwell Health · USUniversity of Illinois Chicago · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Implanted vagus nerve stimulation (VNS) delivered concurrently with upper limb rehabilitation has been shown to improve arm function after stroke. Transcutaneous auricular VNS (taVNS) offers a non-invasive alternative to implanted VNS and may provide similar therapeutic benefit. There is much discussion about the optimal approach for combining VNS and physical therapy, as such we sought to determine whether taVNS administered during robotic training, specifically delivered during the premotor planning stage for arm extension movements, would confer additional motor improvement in patients with chronic stroke. Thirty-six patients with chronic, moderate-severe upper limb hemiparesis (>6 months; mean Upper Extremity Fugl-Meyer score = 25 ± 2, range 13-48), were randomized to receive 9 sessions (1 h in length, 3x/week for 3 weeks) of active (

Indexed as

hemiparesisrehabilitationrobotic therapystroketranscutaneous auricular vagus nerve stimulation (taVNS)vagus nerve stimulation (VNS)

Identifiers

PMID34899170
PMCPMC8655845
OpenAlexW3216015655

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.