Evidence map›Paper›PMID 34899113›Full record

ArticlePlasma processes and polymers (Print)2021

Depyrogenation using Plasmas: A Novel Approach for Endotoxin Deactivation Using a Dielectric Barrier Discharge at Atmospheric Pressure.

Naman Bhatt, Justin Brier-Jones, Duncan Trosan, Cade Brinkley, Joshua Pecoraro, Jann Smallwood, Andrew Crofton, Samuel Hudson, Wolff Kirsch, Katharina Stapelmann and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plasma processes and polymers (Print), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Naman BhattDepartment of Nuclear Engineering, North Carolina State University, North Carolina, USA.
Justin Brier-JonesKaramedica, Inc., North Carolina, USA.
Duncan TrosanDepartment of Nuclear Engineering, North Carolina State University, North Carolina, USA.
Cade BrinkleyDepartment of Nuclear Engineering, North Carolina State University, North Carolina, USA.
Joshua PecoraroDepartment of Nuclear Engineering, North Carolina State University, North Carolina, USA.
Jann SmallwoodNeurosurgery Center for Research, Training, and Education, School of Medicine, Loma Linda University, California, USA.
Andrew CroftonKaramedica, Inc., North Carolina, USA.
Samuel HudsonKaramedica, Inc., North Carolina, USA.
Wolff KirschKaramedica, Inc., North Carolina, USA.
Katharina StapelmannDepartment of Nuclear Engineering, North Carolina State University, North Carolina, USA.
Steven ShannonDepartment of Nuclear Engineering, North Carolina State University, North Carolina, USA.
North Carolina State University · USLoma Linda University · USWakeMed · US

Funding

Microparticle Therapy for Cerebral Amyloid AngiopathyR43AG059478 · NIA · KARAMEDICA, INC. · PI KIRSCH, WOLFF M. · 2018 to 2019
$604k
NIA NIH HHS R43 AG059478
6 · The paper itself

Abstract

Developing a low-cost depyrogenation process is vital in extending medical applicability of polymers that can be used in medicine. We present an overview of the plasma-based depyrogenation literature and address the need to develop a non-thermal plasma-based depyrogenation process for delicate materials such as chitosan. We present a low-cost plasma apparatus to treat chitosan powder in hermetically sealed bags. We decouple the experiments into two; depyrogenation experiments for dried standard endotoxin on glass slides, and chitosan modifications analysis through FTIR spectroscopy. We demonstrate depyrogenation efficacy with up to a 4-log reduction in endotoxin levels and discuss minor changes observed in plasma-treated chitosan.

Indexed as

atmospheric pressure plasmaschitosandepyrogenationendotoxin deactivationlow-temperature plasmas

Identifiers

PMID34899113
PMCPMC8654132
OpenAlexW3198024839

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.