Evidence map›Paper›PMID 34899053›Full record

ArticleMediators of inflammation2021

The Effect of Race and Shear Stress on CRP-Induced Responses in Endothelial Cells.

Chenyi Ling, Marc D Cook, Heather Grimm, Maitha Aldokhayyil, Dulce Gomez, Michael Brown

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Chenyi LingDepartment of Kinesiology & Nutrition, University of Illinois at Chicago, Chicago, IL 60607, USA.ORCID https://orcid.org/0000-0002-6063-8052
Marc D CookDepartment of Kinesiology & Nutrition, University of Illinois at Chicago, Chicago, IL 60607, USA.
Heather GrimmDepartment of Kinesiology & Nutrition, University of Illinois at Chicago, Chicago, IL 60607, USA.
Maitha AldokhayyilDepartment of Kinesiology & Nutrition, University of Illinois at Chicago, Chicago, IL 60607, USA.
Dulce GomezSchool of Kinesiology, Auburn University, Auburn, AL 36849, USA.ORCID https://orcid.org/0000-0003-3245-7083
Michael BrownDepartment of Kinesiology & Nutrition, University of Illinois at Chicago, Chicago, IL 60607, USA.ORCID https://orcid.org/0000-0002-5374-1094
University of Illinois Chicago · USAuburn University · USNorth Carolina Agricultural and Technical State University · USUniversity of Alaska Fairbanks · US

Funding

NRSA Training CoreTL1TR003106 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SAAG, KENNETH G · 2019 to 2023
$3.7M
Genetics of In Vivo and In Vitro Endothelial Function in African AmericansR01HL085497 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI BROWN, MICHAEL DAVID · 2007 to 2011
$3.3M
NCATS NIH HHS TL1 TR003106NHLBI NIH HHS R01 HL085497
6 · The paper itself

Abstract

backgroundC-reactive protein (CRP) is an independent biomarker of systemic inflammation and a predictor of future cardiovascular disease (CVD). More than just a pure bystander, CRP directly interacts with endothelial cells to decrease endothelial nitric oxide synthase (eNOS) expression and bioactivity, decrease nitric oxide (NO) production, and increase the release of vasoconstrictors and adhesion molecules. Race is significantly associated with CRP levels and CVD risks. With aerobic exercise, the vessel wall is exposed to chronic high laminar shear stress (HiLSS) that shifts the endothelium phenotype towards an anti-inflammatory, antioxidant, antiapoptotic, and antiproliferative environment. Thus, the purpose of this study was to assess the racial differences concerning the CRP-induced effects in endothelial cells and the potential role of HiLSS in mitigating these differences.

methodsHuman umbilical vein endothelial cells (HUVECs) from four African American (AA) and four Caucasian (CA) donors were cultured and incubated under the following conditions: (1) static control, (2) CRP (10

resultsAA HUVECs had significantly higher Fc

conclusionUnderstanding potential racial differences in endothelial function is important to improve CVD prevention. Our results shed light on Fc

Indexed as

Black or African AmericanCardiovascular DiseasesCells, CulturedC-Reactive ProteinHumansHuman Umbilical Vein Endothelial CellsNitric Oxide Synthase Type IIIReceptors, IgGStress, MechanicalWhite PeopleC-Reactive ProteinFCGR2B protein, humanNitric Oxide Synthase Type IIINOS3 protein, humanReceptors, IgG

Identifiers

PMID34899053
PMCPMC8660250
OpenAlexW3217568647

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.