ArticleJournal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America2021
Additive Functional Cox Model.
Article in Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed.
- Penalized Likelihood-Based Estimation of Stratified Semiparametric Cox Models Under Partly Interval Censoring.Biometrical journal. Biometrische Zeitschrift · 2026Article
- Variable Selection for Fixed and Random Effects in Multilevel Functional Mixed Effects Models.Statistics in medicine · 2026Article
- Joint analysis of longitudinal and recurrent event data: A functional regression approach with autoregressive frailty.Statistical methods in medical research · 2026Article
- Elastic functional Cox regression model with shape predictors.Journal of applied statistics · 2026Article
- Tutorial on Bayesian Functional Regression Using Stan.Statistics in medicine · 2025Article
- Quantile index predictors using R package hyper.gam.Bioinformatics (Oxford, England) · 2025Article
- Functional protein biomarkers based on distributions of expression levels in single-cell imaging data.Bioinformatics (Oxford, England) · 2025Article
- Walking fingerprinting.Journal of the Royal Statistical Society. Series C, Applied statistics · 2024Article
- SpaceANOVA: Spatial Co-occurrence Analysis of Cell Types in Multiplex Imaging Data Using Point Process and Functional ANOVA.Journal of proteome research · 2024Article
- mxfda: a comprehensive toolkit for functional data analysis of single-cell spatial data.Bioinformatics advances · 2024Article
- Recurrent event analysis in the presence of real-time high frequency data via random subsampling.Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America · 2024Article
- Quantile Index Biomarkers Based on Single-Cell Expression Data.Laboratory investigation; a journal of technical methods and pathology · 2023Article
- Fast Multilevel Functional Principal Component Analysis.Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America · 2023Article
- Statistical Analysis of Multiplex Immunofluorescence and Immunohistochemistry Imaging Data.Methods in molecular biology (Clifton, N.J.) · 2023Review
- Fixed-effects inference and tests of correlation for longitudinal functional data.Statistics in medicine · 2022Article
- Scalar on time-by-distribution regression and its application for modelling associations between daily-living physical activity and cognitive functions in Alzheimer's Disease.Scientific reports · 2022Article
- SPF: A spatial and functional data analytic approach to cell imaging data.PLoS computational biology · 2022Article
- A semiparametric risk score for physical activity.Statistics in medicine · 2022Article
- Fast Univariate Inference for Longitudinal Functional Models.Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America · 2022Article
- Diurnal Physical Activity Patterns across Ages in a Large UK Based Cohort: The UK Biobank Study.Sensors (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
We propose the Additive Functional Cox Model to flexibly quantify the association between functional covariates and time to event data. The model extends the linear functional proportional hazards model by allowing the association between the functional covariate and log hazard to vary non-linearly in both the functional domain and the value of the functional covariate. Additionally, we introduce critical transformations of the functional covariate which address the weak model identifiability in areas of information sparsity and discuss their impact on interpretation and inference. We also introduce a novel estimation procedure that accounts for identifiability constraints directly during model fitting. Methods are applied to the National Health and Nutrition Examination Survey (NHANES) 2003-2006 accelerometry data and quantify new and interpretable circadian patterns of physical activity that are associated with all-cause mortality. We also introduce a simple and novel simulation framework for generating survival data with functional predictors which resemble the observed data. The accompanying inferential R software is fast, open source and publicly available. Our data application and simulations are fully reproducible through the accompanying vignette.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.