Evidence map›Paper›PMID 34898691›Full record

ArticleElectrochimica acta2022

Molecularly imprinted polypyrrole based sensor for the detection of SARS-CoV-2 spike glycoprotein.

Vilma Ratautaite, Raimonda Boguzaite, Ernestas Brazys, Almira Ramanaviciene, Evaldas Ciplys, Mindaugas Juozapaitis, Rimantas Slibinskas, Mikhael Bechelany, Arunas Ramanavicius

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Electrochimica acta, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 149 citations in OpenAlex.

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  6. [Molecular imprinting strategies and advances targeting biomembranes].Se pu = Chinese journal of chromatography · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Vilma RatautaiteLaboratory of Nanotechnology, Department of Functional Materials and Electronics, Center for Physical Sciences and Technology, Sauletekio av. 3, Vilnius LT-10257, Lithuania.
Raimonda BoguzaiteLaboratory of Nanotechnology, Department of Functional Materials and Electronics, Center for Physical Sciences and Technology, Sauletekio av. 3, Vilnius LT-10257, Lithuania.
Ernestas BrazysNanoTechnas - Center of Nanotechnology and Materials Science at Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko str. 24, LT-03225, Vilnius, Lithuania.
Almira RamanavicieneNanoTechnas - Center of Nanotechnology and Materials Science at Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko str. 24, LT-03225, Vilnius, Lithuania.
Evaldas CiplysNanoTechnas - Center of Nanotechnology and Materials Science at Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko str. 24, LT-03225, Vilnius, Lithuania.
Mindaugas JuozapaitisNanoTechnas - Center of Nanotechnology and Materials Science at Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko str. 24, LT-03225, Vilnius, Lithuania.
Rimantas SlibinskasNanoTechnas - Center of Nanotechnology and Materials Science at Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko str. 24, LT-03225, Vilnius, Lithuania.
Mikhael BechelanyInstitut Européen des Membranes, IEM, UMR 5635, University of Montpellier, CNRS, ENSCM, 34090 Montpellier, France.
Arunas RamanaviciusDepartment of Physical Chemistry, Institute of Chemistry, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko str. 24, Vilnius LT-03225 Lithuania.
Vilnius University · LTCenter for Physical Sciences and Technology · LTUniversité de Montpellier · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study describes the application of a polypyrrole-based sensor for the determination of SARS-CoV-2-S spike glycoprotein. The SARS-CoV-2-S spike glycoprotein is a spike protein of the coronavirus SARS-CoV-2 that recently caused the worldwide spread of COVID-19 disease. This study is dedicated to the development of an electrochemical determination method based on the application of molecularly imprinted polymer technology. The electrochemical sensor was designed by molecular imprinting of polypyrrole (Ppy) with SARS-CoV-2-S spike glycoprotein (MIP-Ppy). The electrochemical sensors with MIP-Ppy and with polypyrrole without imprints (NIP-Ppy) layers were electrochemically deposited on a platinum electrode surface by a sequence of potential pulses. The performance of polymer layers was evaluated by pulsed amperometric detection. According to the obtained results, a sensor based on MIP-Ppy is more sensitive to the SARS-CoV-2-S spike glycoprotein than a sensor based on NIP-Ppy. Also, the results demonstrate that the MIP-Ppy layer is more selectively interacting with SARS-CoV-2-S glycoprotein than with bovine serum albumin. This proves that molecularly imprinted MIP-Ppy-based sensors can be applied for the detection of SARS-CoV-2 virus proteins.

Indexed as

Conducting polymersCOVID-19Electrochemical determination of virus proteinsMolecularly imprinted polymers (MIPs)Polypyrrole (Ppy)SARS-CoV-2 spike glycoproteinThin layers

Identifiers

PMID34898691
PMCPMC8643074
OpenAlexW3212916338

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.