ArticlePloS one2021
Altered resting-state functional connectivity of the frontal-striatal circuit in elderly with apathy.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Apathy Associated with Alzheimer's Disease.Current Alzheimer research · 2024Pooled it
- Network localization of functional and structural correlates of apathy in Parkinson's disease.Frontiers in systems neuroscience · 2026Article
- A transdiagnostic, multi-modal approach to understanding apathy: Methodological and analytical framework.Neuroimage. Reports · 2025Article
- Fronto-striatal alterations correlate with apathy severity in behavioral variant frontotemporal dementia.Brain imaging and behavior · 2024Article
- Comparing data-driven physiological denoising approaches for resting-state fMRI: implications for the study of aging.Frontiers in neuroscience · 2024Article
- An Update on Apathy in Alzheimer's Disease.Geriatrics (Basel, Switzerland) · 2023Review
- Altered Resting-State Brain Activity and Functional Connectivity in Post-Stroke Apathy: An fMRI Study.Brain sciences · 2023Article
- The neural correlates of apathy in the context of aging and brain disorders: a meta-analysis of neuroimaging studies.Frontiers in aging neuroscience · 2023Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Apathy is defined as reduction of goal-directed behaviors and a common nuisance syndrome of neurodegenerative and psychiatric disease. The underlying mechanism of apathy implicates changes of the front-striatal circuit, but its precise alteration is unclear for apathy in healthy aged people. The aim of our study is to investigate how the frontal-striatal circuit is changed in elderly with apathy using resting-state functional MRI. Eighteen subjects with apathy (7 female, 63.7 ± 3.0 years) and eighteen subjects without apathy (10 female, 64.8 ± 3.0 years) who underwent neuropsychological assessment and MRI measurement were recruited. We compared functional connectivity with/within the striatum between the apathy and non-apathy groups. The seed-to-voxel group analysis for functional connectivity between the striatum and other brain regions showed that the connectivity was decreased between the ventral rostral putamen and the right dorsal anterior cingulate cortex/supplementary motor area in the apathy group compared to the non-apathy group while the connectivity was increased between the dorsal caudate and the left sensorimotor area. Moreover, the ROI-to-ROI analysis within the striatum indicated reduction of functional connectivity between the ventral regions and dorsal regions of the striatum in the apathy group. Our findings suggest that the changes in functional connectivity balance among different frontal-striatum circuits contribute to apathy in elderly.
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