Evidence map›Paper›PMID 34898571›Full record

ArticleCurrent oncology (Toronto, Ont.)2021

Cutaneous Malignancies in Tattoos, a Case Series of Six Patients.

Marike Leijs, Hannah Schaefer, Albert Rübben, Claudio Cacchi, Thomas Rustemeyer, Sebastiaan van der Bent

Abstract read
In one paragraph

Article in Current oncology (Toronto, Ont.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. [Skin cancer in a tattoo].Dermatologie (Heidelberg, Germany) · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Marike LeijsDepartment of Dermatology, St. Nikolaus Hospital, 4700 Eupen, Belgium.ORCID 0000-0002-2911-1025
Hannah SchaeferDepartment of Dermatology and Allergology, RWTH Aachen University, 52074 Aachen, Germany.
Albert RübbenDepartment of Dermatology, St. Nikolaus Hospital, 4700 Eupen, Belgium.ORCID 0000-0002-2704-4754
Claudio CacchiInstitute of Pathology, RWTH Aachen University, 52074 Aachen, Germany.
Thomas RustemeyerAcademic Tattoo Clinic Amsterdam, Department of Dermatology and Allergology, Amsterdam UMC, 1081 HV Amsterdam, The Netherlands.
Sebastiaan van der BentTattoo Clinic (Tattoo Poli), Department of Dermatology, Alrijne Ziekenhuis Leiden, 2334 CK Leiden, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA variety of side effects following the tattooing of the skin were reported over the years. Analytical studies showed that some tattoo inks contain harmful compounds.

methodsWe presented six patient cases with cutaneous malignancies in tattooed skin and performed an extensive literature research.

resultsTwo patients with black ink tattoos that were diagnosed with malignant melanoma raises the number of described cases to 36 patients. One of the patients developed an immunologic reaction limited to the tattoo area after treatment with a targeted immune therapy. In the other patient, the malignancy (malignant melanoma) was fatal. Basal cell carcinoma was seen in four patients with tattoos containing varying ink colors (black, green, red). This increased the number of described patient cases to 18. Although some ink components and their cleavage products have carcinogenic properties, epidemiological evidence for a causative correlation fails. Further epidemiologic studies on tattoos and malignancies, as well as on the appearance of naevi in tattoos, are necessary. Determining the type of mutation might be helpful to separate sun-induced tumors from skin cancers due to other pathogenic mechanisms.

Indexed as

MelanomaSkin NeoplasmsTattooingColoring AgentsHumansInkColoring Agentsbasal cell carcinomaendocrine disruptorsmelanomapolyaromatic hydrocarbonssquamous cell carcinomatattootattoo inktumor promotion

Identifiers

PMID34898571
PMCPMC8628776

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.