Evidence map›Paper›PMID 34898477›Full record

ArticleAging2021

LncRNA SNHG3 promotes gastric cancer cell proliferation and metastasis by regulating the miR-139-5p/MYB axis.

Yan Xie, Li Rong, Min He, Yuyou Jiang, Haiyu Li, Li Mai, Fangzhou Song

Open access · hybridAbstract read
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 37 citations in OpenAlex.

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  14. Long Non-Coding RNA SNHG3 Promotes the Progression of Cholangiocarcinoma by Regulating the miR-151a-3p/STAT5a Axis.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2024
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  20. The Functions and Mechanisms of Long Non-coding RNA SNHGs in Gastric Cancer.Combinatorial chemistry & high throughput screening · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Yan XieMolecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing 400016, China.
Li RongDepartment of Gastroenterology, Bishan Hospital of Chongqing, Chongqing 402760, China.
Min HeMolecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing 400016, China.
Yuyou JiangMolecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing 400016, China.
Haiyu LiChongqing Public Health Medical Center, Chongqing 400036, China.
Li MaiDepartment of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Fangzhou SongMolecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing 400016, China.
Chongqing Medical University · CNChongqing Public Health Medical Center · CNFirst Affiliated Hospital of Chongqing Medical University · CNPeople's Hospital of Bishan District · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The long non-coding RNA (lncRNA) SNHG3 has been shown to play oncogenic roles in several cancer types, but the mechanisms underlying its activity are poorly understood. In this study, we aimed to explore the clinical relevance and mechanistic role of SNHG3 in gastric cancer (GC). We found that SNHG3 expression in GC cell lines and tissues was significantly increased, and the upregulation of this lncRNA was correlated with tumor clinical stage and decreased patient survival. Knocking down SNHG3 in GC cells impaired the proliferative, migratory, and invasive activity

Indexed as

Cell ProliferationAnimalsCell Line, TumorHumansIn Situ Hybridization, FluorescenceMaleMiceMice, Inbred BALB CMice, NudeMicroRNAsMiddle AgedNeoplasm TransplantationOncogene Proteins v-mybPolymerase Chain ReactionRNA, Long NoncodingStomach NeoplasmsMicroRNAsMIRN139 microRNA, humanOncogene Proteins v-mybRNA, Long NoncodingSNHG32 lncRNA, humangastric cancermiR-139-5pMYBSNHG3

Identifiers

PMID34898477
PMCPMC8714158
OpenAlexW4200209467

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.