Evidence map›Paper›PMID 34898278›Full record

ArticleMolecular and cellular biology2022

Reb1, Cbf1, and Pho4 Bias Histone Sliding and Deposition Away from Their Binding Sites.

Samaneh Ghassabi Kondalaji, Gregory D Bowman

Open access · greenAbstract read
In one paragraph

Article in Molecular and cellular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Hexasomal particles: consequence or also consequential?Current opinion in genetics & development · 2024
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Samaneh Ghassabi KondalajiT. C. Jenkins Department of Biophysics, Johns Hopkins Universitygrid.21107.35, Baltimore, Maryland, USA.ORCID 0000-0003-0000-6691
Gregory D BowmanT. C. Jenkins Department of Biophysics, Johns Hopkins Universitygrid.21107.35, Baltimore, Maryland, USA.ORCID 0000-0001-8025-4315
Johns Hopkins University · US

Funding

Structural and Functional Characterization of the Chd1 Chromatin RemodelerR01GM084192 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI BOWMAN, GREGORY DEAN · 2008 to 2024
$6.3M
NIGMS NIH HHS R01 GM084192
6 · The paper itself

Abstract

In transcriptionally active genes, nucleosome positions in promoters are regulated by nucleosome-displacing factors (NDFs) and chromatin-remodeling enzymes. Depletion of NDFs or the RSC chromatin remodeler shrinks or abolishes the nucleosome-depleted regions (NDRs) in promoters, which can suppress gene activation and result in cryptic transcription. Despite their vital cellular functions, how the action of chromatin remodelers may be directly affected by site-specific binding factors like NDFs is poorly understood. Here, we demonstrate that two NDFs, Reb1 and Cbf1, can direct both Chd1 and RSC chromatin-remodeling enzymes

Indexed as

Basic Helix-Loop-Helix Leucine Zipper Transcription FactorsBinding SitesChromatinChromatin Assembly and DisassemblyDNA-Binding ProteinsGene Expression Regulation, FungalHistonesNucleosomesProtein BindingSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscription FactorsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCBF1 protein, S cerevisiaeChromatinDNA-Binding ProteinsHistonesNucleosomesPHO4 protein, S cerevisiaeREB1 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsTranscription Factorscentromere-binding factor 1 (Cbf1)chromatin remodelingchromodomain helicase DNA-binding protein 1 (Chd1)hexasomenucleosomenucleosome-depleted region (NDR)nucleosome-displacing factor (NDF)remodels the structure of chromatin (RSC)RNA polymerase I enhancer binding protein 1 (Reb1)

Identifiers

PMID34898278
PMCPMC8852720
OpenAlexW4200054563

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.