ArticleJournal of the American Chemical Society2021
Self-Immolative Polymers: An Emerging Class of Degradable Materials with Distinct Disassembly Profiles.
Article in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed.
- Metastable Polymers for Circular 3D Printing.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Functional cyclic disulfides enable multi-pathway degradable polyvinyls.Chemical science · 2026Article
- Self-Immolative Gels: Programmable Degradation Using Self-Immolative Linkers and Polymers.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Challenges and Opportunities for Cleavable Linkers Used in Polymer-Drug Conjugates.Journal of the American Chemical Society · 2026Review
- Depolymerization and Reuse of Polycarbonates: Emerging Classes, Mechanisms and Challenges.Angewandte Chemie (International ed. in English) · 2026Review
- Photochemical Fuel Carrier Molecules for Robotic Embodied Energy.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Prodrug-tethered lipid nanoparticles for synergistic messenger RNA cancer immunotherapy.Nature nanotechnology · 2026Article
- Conformational preorganization of neighbouring groups modulates and expedites polymer self-deconstruction.Nature chemistry · 2026Article
- Harnessing Hydrogen Cyanide (HCN): Responsive Chemical Tools for Delivering an Emerging Gasotransmitter.Angewandte Chemie (International ed. in English) · 2026Article
- Standardizing Depolymerization: Strategies and Performance Metrics.Precision chemistry · 2025Review
- Self-Immolative Polyion Complexes.Macromolecular rapid communications · 2025Article
- Lipoic Acid Based Redox-Responsive Degradable Antimicrobial Polymers.Macromolecular rapid communications · 2025Article
- Unimolecular near-infrared chemiluminescent reporter for cascaded multiplex imaging of ischemia-reperfusion injury in the liver-kidney axis.Nature communications · 2025Article
- Functional Self-Immolative Hydrogels with Dendritic Cross-Linkers for Controlled Drug Delivery.Chemistry of materials : a publication of the American Chemical Society · 2025Article
- Mechanochemistry: Fundamental Principles and Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Advances in the Release of Amide-Containing Molecules.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Harnessing Non-Thermal External Stimuli for Polymer Recycling.Macromolecules · 2025Review
- Sustainable synthesis of fine chemicals and polymers using industrial chlorine chemistry.Communications chemistry · 2024Review
- Nonlinear amplification of nano bowl surface concavity on the critical response threshold to biosignals.Nature communications · 2024Article
- Self-immolative poly(thiocarbamate) with localized HNature communications · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Self-immolative polymers are an emerging class of macromolecules with distinct disassembly profiles that set them apart from other general degradable materials. These polymers are programmed to disassemble spontaneously from head to tail, through a domino-like fragmentation, upon response to extremal stimuli. In the time since we first reported this unique type of molecule, several groups around the world have developed new, creative molecular structures that perform analogously to our pioneering polymers. Self-immolative polymers are now widely recognized as an important class of stimuli-responsive materials for a wide range of applications such as signal amplification, biosensing, drug delivery, and materials science. The quinone-methide elimination was shown to be an effective tool to achieve rapid domino-like fragmentation of polymeric molecules. Thus, numerous applications of self-immolative polymers are based on this disassembly chemistry. Although several other fragmentation reactions achieved the function requested for sequential disassembly, we predominantly focused in this Perspective on examples of self-immolative polymers that disassemble through the quinone-methide elimination. Selected examples of self-immolative polymers that disassembled through other chemistries are briefly described. The growing demand for stimuli-responsive degradable materials with novel molecular backbones and enhanced properties guarantees the future interest of the scientific community in this unique class of polymers.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.