Evidence map›Paper›PMID 34898198›Full record

ArticleJournal of the American Chemical Society2021

BesC Initiates C-C Cleavage through a Substrate-Triggered and Reactive Diferric-Peroxo Intermediate.

Olivia M Manley, Haoyu Tang, Shan Xue, Yisong Guo, Wei-Chen Chang, Thomas M Makris

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Heme oxygenase-like dimetal oxidases and oxygenases.Biochemical Society transactions · 2026
    Review
  5. Article
  6. Article
  7. A ferritin-like diiron oxygenase BioE initiates bacterial biotin synthesis, a promising antivirulence target.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
  9. Article
  10. Heme Oxygenase-Like Metalloenzymes.Annual review of biochemistry · 2025
    Review
  11. Article
  12. Biochemical characterization of the self-sacrificing p-aminobenzoate synthase from Nitrosomonas europaea reveals key residues involved in selecting a Fe/Fe or Mn/Fe cofactor.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025
    Article
  13. Copper-chelating natural products.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025
    Review
  14. Article
  15. Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Olivia M ManleyDepartment of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.
Haoyu TangDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.
Shan XueDepartment of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States.
Yisong GuoDepartment of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States.ORCID 0000-0002-4132-3565
Wei-Chen ChangDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.ORCID 0000-0002-2341-9846
Thomas M MakrisDepartment of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.ORCID 0000-0001-7927-620X
North Carolina State University · USCarnegie Mellon University · US

Funding

Understanding How Nonheme Iron-Dependent Enzymes Assemble Pharmacophores: Studies of Cyclopropane, Aziridine, and Isonitrile FormationR01GM127588 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Wei-chen Chang · 2018 to 2026
$3.3M
Elucidate Mechanisms of Quinolone Alkaloid Biosynthesis via Iron(II)/2-Oxoglutarate Dependent Enzymes: Diverse, but Controlled ReactivityR01GM125924 · NIGMS · CARNEGIE-MELLON UNIVERSITY · PI Yisong Guo · 2018 to 2026
$3.3M
Divergence of Carboxylate-Bridged Diiron Enzymes for Natural Product BiosynthesisR01GM135315 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI MAKRIS, THOMAS M · 2019 to 2022
$1.4M
NIGMS NIH HHS R01 GM125924NIGMS NIH HHS R01 GM127588NIGMS NIH HHS R01 GM135315
6 · The paper itself

Abstract

BesC catalyzes the iron- and O

Indexed as

CarbonFerric CompoundsOxidoreductasesOxygenSpectroscopy, MossbauerStreptomycesSubstrate SpecificityCarbonFerric CompoundsOxidoreductasesOxygen

Identifiers

PMID34898198
PMCPMC8876372
OpenAlexW4200233291

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.