Evidence map›Paper›PMID 34897954›Full record

ArticleEMBO reports2022

An ongoing science-society-ethics experiment: The human challenge trial debate in COVID-19 pandemic: The human challenge trial debate in COVID-19 pandemic.

Sonia M R Vasconcelos, Angela Esher, Carmen Penido, Cleide Lima, Karina A Rocha, Maria Júlia M Antunes, Mariana D Ribeiro, Marlise Pedrotti

Open access · bronzeAbstract read
In one paragraph

Article in EMBO reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Sonia M R VasconcelosScience Education Program/Institute of Medical Biochemistry Leopoldo de Meis (IBqM), Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.ORCID 0000-0001-6315-6510
Angela EsherSergio Arouca National School for Public Health (ENSP)/Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil.ORCID 0000-0002-7473-8636
Carmen PenidoCenter for Technological Development in Health (CDTS)/Institute of Drug Technology (Farmanguinhos)/FIOCRUZ, Rio de Janeiro, Brazil.ORCID 0000-0003-0209-4410
Cleide LimaProfessional Masters Program/IBqM/UFRJ, Rio de Janeiro, Brazil.ORCID 0000-0003-3539-9405
Karina A RochaScience Education Program/Institute of Medical Biochemistry Leopoldo de Meis (IBqM), Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.ORCID 0000-0001-8165-7888
Maria Júlia M AntunesScience Education Program/Institute of Medical Biochemistry Leopoldo de Meis (IBqM), Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.ORCID 0000-0003-3148-9198
Mariana D RibeiroScience Education Program/Institute of Medical Biochemistry Leopoldo de Meis (IBqM), Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.ORCID 0000-0002-0416-071X
Marlise PedrottiScience Education Program/Institute of Medical Biochemistry Leopoldo de Meis (IBqM), Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.ORCID 0000-0002-7623-4482
Universidade Federal do Rio de Janeiro · BRFundação Oswaldo Cruz · BRIBM Research - Brazil · BRNational Institute of Science and Technology of Drugs and Medicines · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human challenge trials to deliberately infect volunteers with SARS-CoV-2 should inspire wider debates about research ethics and participants' motivations to take part in such studies.

Indexed as

COVID-19PandemicsEthics, ResearchHumansSARS-CoV-2

Identifiers

PMID34897954
PMCPMC8728609
OpenAlexW4200620969

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.