Evidence map›Paper›PMID 34897892›Full record

ArticleCancer science2022

Hypoxia-inducible lncRNA MIR210HG interacting with OCT1 is involved in glioblastoma multiforme malignancy.

Kuo-Hao Ho, Chwen-Ming Shih, Ann-Jeng Liu, Ku-Chung Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 50 citations in OpenAlex.

  1. Review
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  10. LncRNA-Mediated TPI1 and PKM2 Promote Self-Renewal and Chemoresistance in GBM.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
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  16. A novel intronic circular RNA circFGFR1Journal of translational medicine · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kuo-Hao HoGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Chwen-Ming ShihGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Ann-Jeng LiuDepartment of Neurosurgery, Taipei City Hospital Ren-Ai Branch, Taipei, Taiwan.
Ku-Chung ChenGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.ORCID https://orcid.org/0000-0002-4696-3924
Taipei Medical University · TWTaipei City Hospital · TW

Funding

Ministry of Science and Technology, Taiwan MOST 110-2320-B-038-069Taipei City Government 11001-62-022Taipei City Government 11101-62-030Taipei City Hospital Ren-Ai TPCH-110-07
6 · The paper itself

Abstract

An insufficient oxygen supply within the intratumoral environment, also known as hypoxia, induces glioblastoma multiforme (GBM) invasion, stemness, and temozolomide (TMZ) drug resistance. Long noncoding (lnc)RNAs have been reported to be involved in hypoxia and GBM progression. However, their roles in hypoxic GBM malignancy are still unclear. We investigated the mechanisms of hypoxia-mediated lncRNAs in regulating GBM processes. Using The Cancer Genome Atlas (TCGA) and data mining, hypoxia-correlated lncRNAs were identified. A hypoxia-upregulated lncRNA, MIR210HG, locating in nuclear regions, predicted poor prognoses of patients and modulated hypoxia-promoted glioma stemness, TMZ resistance, and invasion. Depletion of hypoxic MIR210HG suppressed GBM and patient-derived cell growth and increased TMZ sensitivity in vitro and vivo. Using RNA sequencing and gene set enrichment analysis (GSEA), MIR210HG-upregulated genes significantly belonged to the targets of octamer transcription factor 1 (OCT1) transcription factor. The direct interaction between OCT1 and MIR210HG was also validated. Two well-established worse prognostic factors of GBM, insulin-like growth factor-binding protein 2 (IGFBP2) and fibroblast growth factor receptor 1 (FGFR1), were identified as downstream targets of OCT1 through MIR210HG mediation in hypoxia. Consequently, the lncRNA MIR210HG is upregulated by hypoxia and interacts with OCT1 for modulating hypoxic GBM, leading to poor prognoses. These findings might provide a better understanding in functions of hypoxia/MIR210HG signaling for regulating GBM malignancy.

Indexed as

AnimalsAntineoplastic Agents, AlkylatingCell Line, TumorCell Transformation, NeoplasticDrug Resistance, NeoplasmGene Expression Regulation, NeoplasticGlioblastomaHumansInsulin-Like Growth Factor Binding Protein 2MiceOctamer Transcription Factor-1PrognosisReceptor, Fibroblast Growth Factor, Type 1RNA, Long NoncodingSignal TransductionTemozolomideAntineoplastic Agents, AlkylatingFGFR1 protein, humanIGFBP2 protein, humanInsulin-Like Growth Factor Binding Protein 2Octamer Transcription Factor-1POU2F1 protein, humanReceptor, Fibroblast Growth Factor, Type 1RNA, Long NoncodingTemozolomideFGFR1hypoxic glioblastomaIGFBP2MIR210HGOCT1

Identifiers

PMID34897892
PMCPMC8819343
OpenAlexW4200383040

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.