ArticleHuman brain mapping2022
Effects of gestational age at birth on perinatal structural brain development in healthy term-born babies.
Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Cognitive and academic outcomes of large-for-gestational-age babies born at early term: A systematic review and meta-analysis.Acta obstetricia et gynecologica Scandinavica · 2025Pooled it
- The Earliest Impressions: A Systematic Review of Early-Life Exposures on Brain Structure and Neurodevelopmental Outcomes.bioRxiv : the preprint server for biology · 2026Article
- Individual variability in neural correlates of visual engagement in premature toddlers.Developmental cognitive neuroscience · 2026Article
- Dynamics of infant white matter maturation from birth to 6 months.Communications biology · 2026Article
- Fetal size, gestational age, and cognitive performance at 5 years in term-born children: Four national cohorts' study.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Article
- Short-Term Neonatal Outcomes Following Early-Term vs. Full-Term and Late-Preterm Births: Insights from a Retrospective Cohort Study.Children (Basel, Switzerland) · 2025Article
- Autism spectrum disorder common variants associated with regional lobe volume variations at birth: cross-sectional study in 273 European term neonates in developing human connectome project.Translational psychiatry · 2025Article
- Gestational Duration and Postnatal Age-Related Changes in Aperiodic and Periodic Parameters in Neonatal and Toddler Electroencephalogram (EEG).Human brain mapping · 2025Article
- Association of early-term birth and breastfeeding practices with nutritional outcomes in singleton term infants: a multicenter cross-sectional study.International breastfeeding journal · 2024Article
- Association of maternal postpartum depression symptoms with infant neurodevelopment and gut microbiota.Frontiers in psychiatry · 2024Article
- Prenatal exposure to air pollution is associated with structural changes in the neonatal brain.Environment international · 2023Article
- Effects of gestational age at birth on perinatal structural brain development in healthy term-born babies.Human brain mapping · 2022Article
Corrections and comments
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Authors and funding
22 authors at 2 institutions in 4 countries.
Funding
Abstract
Infants born in early term (37-38 weeks gestation) experience slower neurodevelopment than those born at full term (40-41 weeks gestation). While this could be due to higher perinatal morbidity, gestational age at birth may also have a direct effect on the brain. Here we characterise brain volume and white matter correlates of gestational age at birth in healthy term-born neonates and their relationship to later neurodevelopmental outcome using T2 and diffusion weighted MRI acquired in the neonatal period from a cohort (n = 454) of healthy babies born at term age (>37 weeks gestation) and scanned between 1 and 41 days after birth. Images were analysed using tensor-based morphometry and tract-based spatial statistics. Neurodevelopment was assessed at age 18 months using the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III). Infants born earlier had higher relative ventricular volume and lower relative brain volume in the deep grey matter, cerebellum and brainstem. Earlier birth was also associated with lower fractional anisotropy, higher mean, axial, and radial diffusivity in major white matter tracts. Gestational age at birth was positively associated with all Bayley-III subscales at age 18 months. Regression models predicting outcome from gestational age at birth were significantly improved after adding neuroimaging features associated with gestational age at birth. This work adds to the body of evidence of the impact of early term birth and highlights the importance of considering the effect of gestational age at birth in future neuroimaging studies including term-born babies.
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Registered trials
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