Evidence map›Paper›PMID 34897715›Full record

ReviewJournal of surgical oncology2022

Melanoma trials that defined surgical management: Overview of trials that established NCCN margin guidelines.

Jeremy Sharib, Craig L Slingluff, Georgia M Beasley

Abstract readHistorical ArticleReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of surgical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jeremy SharibDepartment of Surgery, Duke University, Durham, North Carolina, USA.ORCID http://orcid.org/0000-0002-1047-9823
Craig L SlingluffDepartment of Surgery, University of Virginia, Charlottesville, Virginia, USA.ORCID http://orcid.org/0000-0002-6664-4373
Georgia M BeasleyDepartment of Surgery, Duke University, Durham, North Carolina, USA.ORCID http://orcid.org/0000-0001-6387-9030

Funding

PVSRIPO in melanomaK08CA237726 · NCI · DUKE UNIVERSITY · PI BEASLEY, GEORGIA · 2020 to 2024
$1.0M
National Institute of Health K08 CA237726-01A1NCI NIH HHS K08 CA237726
6 · The paper itself

Abstract

Since the observation that clearance of all visible and microscopic tumors from cutaneous melanoma is critical to prevent a recurrence, wide surgical margins have been central to surgical dogma. In the last several decades, more conservative margin widths have been vigorously studied by surgical investigators to lessen wound complications, the need for reconstruction, and healthcare costs. This review summarizes surgeon-led clinical trials that define current guidelines and highlights the challenges to initiate and perform trials today.

Indexed as

Clinical Trials as TopicCutaneous Malignant MelanomaCytoreduction Surgical ProceduresHistory, 20th CenturyHistory, 21st CenturyHumansMargins of ExcisionMelanomaPractice Guidelines as TopicRandomized Controlled Trials as TopicSkin Neoplasmsclinical trialsmarginsmelanoma

Identifiers

PMID34897715
PMCPMC8682801

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.