Evidence map›Paper›PMID 34897710›Full record

ArticleJournal of surgical oncology2022

Registry-based randomized clinical trials in surgery: Working with ACS-NSQIP and the AHPBA to conduct pragmatic trials.

Brett L Ecker, Brian C Brajcich, Ryan J Ellis, Clifford Y Ko, Michael I D'Angelica

Abstract read
In one paragraph

Article in Journal of surgical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Brett L EckerDivision of Hepatopancreatobiliary Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.ORCID https://orcid.org/0000-0003-2536-9261
Brian C BrajcichDepartment of Surgery, Surgical Outcomes and Quality Improvement Center, Northwestern Medicine, Chicago, Illinois, USA.
Ryan J EllisDivision of Hepatopancreatobiliary Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Clifford Y KoDivision of Research and Optimal Patient Care, American College of Surgeons, Chicago, Illinois, USA.
Michael I D'AngelicaDivision of Hepatopancreatobiliary Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
COllaborative Northwestern Surgical Oncology Research Training (CONSORT)T32CA247801 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ACKERMANN, RONALD T., KHAN, SEEMA AHSAN · 2020 to 2024
$1.3M
NCI NIH HHS P30 CA008748NCI NIH HHS P30CA008748NCI NIH HHS T32 CA247801NCI NIH HHS T32CA247801
6 · The paper itself

Abstract

Randomized controlled trials (RCTs) represent the gold standard for evidence in clinical medicine because of their ability to account for the effects of unmeasured confounders and selection bias by indication. However, their complexity and immense costs limit their application, and thus the availability of high-quality data to guide clinical care. Registry-based RCTs are a type of pragmatic trial that leverages existing registries as a platform for data collection, providing a low-cost alternative for randomized studies. Herein, we describe the tenets of registry RCTs and the development of the first AHPBA/ACS-NSQIP-based registry trial.

Indexed as

Randomized Controlled Trials as TopicRegistriesHumansNeoplasmsQuality of Health CareSurgical Oncologypragmatic clinical trialrandomized controlled trialsregistry-based trialssurgical registrysurgical research methods

Identifiers

PMID34897710
PMCPMC8787438

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.