Evidence map›Paper›PMID 34897654›Full record

ReviewJournal of the American Geriatrics Society2022

Medication use quality and safety in older adults: 2020 update.

Tesfahun C Eshetie, Zachary A Marcum, Kenneth E Schmader, Shelly L Gray

Open access · greenAbstract readReview
In one paragraph

Review in Journal of the American Geriatrics Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Tesfahun C EshetiePlein Center for Geriatric Pharmacy Research, Education and Outreach, School of Pharmacy, University of Washington, Seattle, Washington, USA.ORCID 0000-0001-7253-988X
Zachary A MarcumPlein Center for Geriatric Pharmacy Research, Education and Outreach, School of Pharmacy, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-4690-2304
Kenneth E SchmaderDepartment of Medicine (Geriatrics), School of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Shelly L GrayPlein Center for Geriatric Pharmacy Research, Education and Outreach, School of Pharmacy, University of Washington, Seattle, Washington, USA.
University of Washington · USGeriatric Research Education and Clinical Center · US

Funding

Furthering scientific understanding of mechanisms underlying resilience to the effects of AD pathology by incorporating state of the art quantification of gliosis, inflammation, & synaptic toxicityU01AG006781 · NIA · UNIVERSITY OF WASHINGTON · PI CRANE, PAUL K, LARSON, ERIC B · 1986 to 2020
$39.3M
Resource Core 3 - Metabolomics CoreP30AG028716 · NIA · DUKE UNIVERSITY · PI Sarah B. Peskoe · 2006 to 2026
$24.6M
U.S. Deprescribing Research NetworkR24AG064025 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI BOYD, CYNTHIA MELINDA, STEINMAN, MICHAEL A. · 2019 to 2023
$9.9M
Reducing CNS-active Medications to Prevent Falls and Injuries in Older AdultsU01CE002967 · CE · UNIVERSITY OF WASHINGTON · PI GRAY, SHELLY L, PHELAN, ELIZABETH ANNE · 2018 to 2021
$2.9M
Antihypertensives and the Aging BrainK76AG059929 · NIA · UNIVERSITY OF WASHINGTON · PI MARCUM, ZACHARY ADAM · 2019 to 2021
$694k
ACL HHS U01CE002967CDC HHS U01CE002967NCIPC CDC HHS U01 CE002967NIA NIH HHS 1R24AG064025NIA NIH HHS K76 AG059929NIA NIH HHS K76AG059929NIA NIH HHS P30 AG028716NIA NIH HHS P30AG028716NIA NIH HHS R24 AG064025NIA NIH HHS U01 AG006781NIA NIH HHS U01AG006781
6 · The paper itself

Abstract

Improving the quality of medication use and medication safety are important priorities for prescribers who care for older adults. The objective of this article was to identify four exemplary articles with this focus in 2020. We selected high-quality studies that moved the field of research forward and were not merely replication studies. The chosen articles cover domains related to deprescribing, medication safety, and optimizing medication use. The first study, a noninferiority randomized clinical trial in England, evaluated whether antihypertensive medication reduction is possible without significant changes in systolic blood pressure control or adverse events over the 12-week follow-up (domain: deprescribing). The second study, a prospective cohort study of women at Kaiser Permanente Southern, California, examined the association between bisphosphonate use and atypical femur fracture (domain: medication safety). The third study examined the effectiveness and safety of a multifaceted antimicrobial stewardship and quality improvement initiative in reducing unnecessary antimicrobial use for unlikely cystitis cases in noncatheterized residents in 25 nursing homes across the United States (domain: optimizing medication use). Lastly, the fourth study, a population-based cohort study in the United Kingdom, examined the association of tramadol use with risk of hip fracture (domain: medication safety). Collectively, this review succinctly highlights pertinent topics related to promoting safe use of medications and promotes awareness of optimizing older adults' medication regimens.

Indexed as

Antimicrobial StewardshipDeprescriptionsInappropriate PrescribingPatient SafetyPolypharmacyAged, 80 and overAnalgesics, OpioidAntihypertensive AgentsCaliforniaCystitisDiphosphonatesHospitalizationHumansProspective StudiesRandomized Controlled Trials as TopicTramadolAnalgesics, OpioidAntihypertensive AgentsDiphosphonatesTramadol80 years and overageddeprescriptioninappropriate prescribingmedication-related problemspolypharmacy

Identifiers

PMID34897654
PMCPMC8821136
OpenAlexW4200113928

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.