Evidence map›Paper›PMID 34897598›Full record

ArticleDiving and hyperbaric medicine2021

Microcirculation and tissue oxygenation in the head and limbs during hyperbaric oxygen treatment.

Naoki Yamamoto, Ryohei Takada, Takuma Maeda, Toshitaka Yoshii, Atsushi Okawa, Kazuyoshi Yagishita

Open access · greenAbstract read
In one paragraph

Article in Diving and hyperbaric medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Oxygen Therapy for Intracranial Hemorrhage.CNS neuroscience & therapeutics · 2026
    Review
  2. Review
  3. Observational
  4. Hyperoxia: Effective Mechanism of Hyperbaric Treatment at Mild-Pressure.International journal of molecular sciences · 2024
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Naoki YamamotoDepartment of Orthopaedic Surgery, Tokyo Medical and Dental University Hospital, Tokyo, Japan.
Ryohei TakadaDepartment of Orthopaedic Surgery, Tokyo Medical and Dental University Hospital, Tokyo, Japan.
Takuma MaedaHyperbaric Medical Centre, Tokyo Medical and Dental University Hospital, Tokyo, Japan.
Toshitaka YoshiiDepartment of Orthopaedic Surgery, Tokyo Medical and Dental University Hospital, Tokyo, Japan.
Atsushi OkawaDepartment of Orthopaedic Surgery, Tokyo Medical and Dental University Hospital, Tokyo, Japan.
Kazuyoshi YagishitaDepartment of Orthopaedic Surgery, Tokyo Medical and Dental University Hospital, Tokyo, Japan.
Tokyo Medical and Dental University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHyperbaric oxygen (HBO) exposure for 10-15 min has been shown to reduce peripheral blood flow due to vasoconstriction. However, the relationship between decreased peripheral blood flow and the therapeutic effects of HBO treatment on peripheral circulatory disorders remain unknown. Longer exposures have been reported to have vasodilatory effects and increase peripheral blood flow. This study investigated the effect of HBO treatment on blood flow and transcutaneous oxygen pressure (TcPO

methodsTwenty healthy volunteers aged 20-65 years (nine males) participated in this study. All participants breathed oxygen for 60 min at 253.3 kPa. Peripheral blood flow using laser Doppler flowmetry and TcPO

resultsPeripheral blood flow in each body part decreased by 7-23% at the beginning of the HBO exposure, followed by a slow increase. Post-exposure, peripheral blood flow increased 4-76% in each body part. TcPO

conclusionsThe findings of the current study suggest vasoconstriction during HBO treatment is transient, and even when present does not inhibit the development of increased tissue oxygen partial pressure. These findings are relevant to studies investigating changes in peripheral blood flow during HBO treatment in patients with circulatory disorders.

Indexed as

Hyperbaric OxygenationHandHumansMaleMicrocirculationOxygenTime FactorsOxygenCardiovascularHyperoxiaLaser DopplerPatient monitoringPeripheral blood flowTranscutaneous oximetry

Identifiers

PMID34897598
PMCPMC8920905
OpenAlexW4200427287

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.