ArticleAnnals of intensive care2021
Association between mortality and age among mechanically ventilated COVID-19 patients: a Japanese nationwide COVID-19 database study.
Article in Annals of intensive care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- A multicenter machine learning model for predicting ICU mortality in mechanically ventilated patients: development and external validation.BMC medical informatics and decision making · 2026Article
- The COVIDTW3 Study: Impact of Variants of Concern and Vaccination on Mortality in Intubated Patients with COVID-19-Related Respiratory Failure from 2021 to 2023.Biomedicines · 2026Article
- One-Year Survival and Changes in Care Needs Among Hospitalized Older Patients With Coronavirus Disease 2019 in Japan: A Nara Kokuho Database Analysis.Geriatrics & gerontology international · 2026Article
- Guidelines for the Initial Assessment of Respiratory Distress in the Emergency Department.Annals of intensive care · 2026Article
- Article
- Impact of the COVID-19 pandemic on prehospital and in-hospital treatment and outcomes of patients after out-of-hospital cardiac arrest: a Japanese multicenter cohort study.BMC emergency medicine · 2024Article
- Physical function and mental health trajectories in COVID-19 patients following invasive mechanical ventilation: a prospective observational study.Scientific reports · 2023Observational
- Risk Factors Associated with Mortality among Mechanically Ventilated Patients with Coronavirus Disease 2019 Pneumonia: A Multicenter Cohort Study in Japan (J-RECOVER Study).Internal medicine (Tokyo, Japan) · 2023Article
- Efficacy of cefiderocol- vs colistin-containing regimen for treatment of bacteraemic ventilator-associated pneumonia caused by carbapenem-resistant Acinetobacter baumannii in patients with COVID-19.International journal of antimicrobial agents · 2023Observational
- Significant Impact of Age on Mortality and Non-significant Impact of Age on Thrombosis and Major Bleeding in Patients with COVID-19: From the CLOT-COVID Study.Journal of atherosclerosis and thrombosis · 2023Observational
- Impact of COVID-19 on the Surrounding Environment of Nursing Home Residents and Attitudes towards Infection Control and Oral Health Care among Nursing Home Staff in Japan.Journal of clinical medicine · 2023Article
- Comparison of Azvudine and Nirmatrelvir/Ritonavir and Combined Use in Patients with COVID-19.Infection and drug resistance · 2023Article
- Efficacy of Early Rehabilitation for Severe Coronavirus Disease 2019 Pneumonia: Factor Analysis Using Machine Learning.Progress in rehabilitation medicine · 2023Article
- The new combination of oxygen saturation with age shock index predicts the outcome of COVID-19 pneumonia.SAGE open medicine · 2023Article
- Review
- Patient-centered outcomes at hospital discharge in mechanically ventilated COVID-19 patients in Kobe, Japan: A single-center retrospective cohort study.Respiratory investigation · 2022Article
- Japanese Multicenter Research of COVID-19 by Assembling Real-world Data: A Study Protocol.Annals of clinical epidemiology · 2022Article
- Risk factors for the need for advanced care among prescription and over-the-counter drug overdose patients.Acute medicine & surgeryArticle
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17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOnly a few studies have reported the association between age and mortality in COVID-19 patients who require invasive mechanical ventilation (IMV). We aimed to evaluate the effect of age on COVID-19-related mortality among patients undergoing IMV therapy.
methodsThis cohort study was conducted using the COVID-19 Registry Japan database, a nationwide multi-centre study of hospitalized patients with laboratory-confirmed COVID-19. Of all 33,808 cases registered between 1 January 2020 to 28 February 2021, we analysed 1555 patients who had undergone IMV. We evaluated mortality rates between age groups using multivariable regression analysis after adjusting for known potential components, such as within-hospital clustering, comorbidities, steroid use, medication for COVID-19, and vital signs on admission, using generalized estimation equation.
resultsBy age group, the mortality rates in the IMV group were 8.6%, 20.7%, 34.9%, 49.7% and 83.3% for patients in their 50s, 60s, 70s, 80s, and 90s, respectively. Multivariable analysis showed that compared with those for patients aged < 60 years, the odds ratios (95% confidence interval) of death were 2.6 (1.6-4.1), 6.9 (4.2-11.3), 13.2 (7.2-24.1), 92.6 (16.7-515.0) for patients in their 60s, 70s, 80s, and 90s, respectively.
conclusionsIn this cohort study, age had a great effect on mortality in COVID-19 patients undergoing IMV, after adjusting for variables independently associated with mortality. This study suggested that age was associated with higher mortality and that preventing progression to severe COVID-19 in elderly patients may be a great public health issue.
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