Evidence map›Paper›PMID 34897556›Full record

ArticleEJNMMI physics2021

Nonclinical study and applicability of the absorbed dose conversion method with a single biodistribution measurement for targeted alpha-nuclide therapy.

Tetsuya Sakashita, Shojiro Matsumoto, Shigeki Watanabe, Hirofumi Hanaoka, Yasuhiro Ohshima, Yoko Ikoma, Naoyuki Ukon, Ichiro Sasaki, Tatsuya Higashi, Tetsuya Higuchi and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tetsuya SakashitaQuantum Beam Science Research Directorate, National Institutes for Quantum Science and Technology, 1233 Watanuki-machi, Takasaki, 370-1292, Japan. sakashita.tetsuya@qst.go.jp.ORCID http://orcid.org/0000-0002-3357-8373
Shojiro MatsumotoQuantum Beam Science Research Directorate, National Institutes for Quantum Science and Technology, 1233 Watanuki-machi, Takasaki, 370-1292, Japan.
Shigeki WatanabeQuantum Beam Science Research Directorate, National Institutes for Quantum Science and Technology, 1233 Watanuki-machi, Takasaki, 370-1292, Japan.
Hirofumi HanaokaDepartment of Bioimaging Information Analysis, Gunma University Graduate School of Medicine, 3-39-22 Showa, Maebashi, 371-8511, Japan.
Yasuhiro OhshimaQuantum Beam Science Research Directorate, National Institutes for Quantum Science and Technology, 1233 Watanuki-machi, Takasaki, 370-1292, Japan.
Yoko IkomaDepartment of Molecular Imaging and Theranostics, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, Japan.
Naoyuki UkonAdvanced Clinical Research Center, Fukushima Medical University, 1 Hikariga-oka, Fukushima, 960-1295, Japan.
Ichiro SasakiQuantum Beam Science Research Directorate, National Institutes for Quantum Science and Technology, 1233 Watanuki-machi, Takasaki, 370-1292, Japan.
Tatsuya HigashiDepartment of Molecular Imaging and Theranostics, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, Japan.
Tetsuya HiguchiDepartment of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa, Maebashi, 371-8511, Japan.
Yoshito TsushimaDepartment of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa, Maebashi, 371-8511, Japan.
Noriko S IshiokaQuantum Beam Science Research Directorate, National Institutes for Quantum Science and Technology, 1233 Watanuki-machi, Takasaki, 370-1292, Japan.

Funding

KAKENHI JP19H04296
6 · The paper itself

Abstract

backgroundWe recently reported a new absorbed dose conversion method, RAP (RAtio of Pharmacokinetics), for

methodsWe derived a new formalism of the RAP dose conversion method at time t. In addition, we acquired a formula to determine the optimal timing of a single measurement of the percent injected dose/g, assuming the one-compartment model for biological clearance.

resultsWe investigated the new formalism's performance using a representative RAP coefficient with radioactive decay weighting. Dose conversions by representative RAP coefficients predicted the true [

conclusionsThe RAP dose conversion method renovated by the new formalism was able to estimate the [

Indexed as

BiodistributionDose conversionPharmacokineticsRAPTargeted alpha-nuclide therapy

Identifiers

PMID34897556
PMCPMC8665908

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.