Evidence map›Paper›PMID 34897512›Full record

ArticleNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2022

Serum Concentrations of Cotinine and Trans-3'-Hydroxycotinine in US Adults: Results From Wave 1 (2013-2014) of the Population Assessment of Tobacco and Health Study.

Connie S Sosnoff, Kevin Caron, J Ricky Akins, Kristin Dortch, Ronald E Hunter, Brittany N Pine, June Feng, Benjamin C Blount, Yao Li, Dana M van Bemmel and 16 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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  9. Urinary Nicotine Metabolites and Self-Reported Tobacco Use Among Adults in the Population Assessment of Tobacco and Health (PATH) Study, 2013-2014.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 6 institutions in 1 country.

Connie S SosnoffDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.ORCID 0000-0001-9162-633X
Kevin CaronDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
J Ricky AkinsDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Kristin DortchDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Ronald E HunterDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Brittany N PineDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
June FengDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Benjamin C BlountDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Yao LiDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Dana M van BemmelOffice of Science, Center for Tobacco Products, U.S. Food and Drug Administration, Silver Spring, MD, USA.
Heather L KimmelDivision of Epidemiology, Services and Prevention Research, National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-8278-0095
Kathryn C EdwardsBehavioral Health and Health Policy, Westat, Rockville, MD, USA.
Maciej L GoniewiczRoswell Park Comprehensive Cancer Center, Roswell Park Cancer Institute , Buffalo, NY, USA.
Dorothy K HatsukamiMasonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-1108-2609
B Rey de CastroDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
John T BernertDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Stephen ArnsteinDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Nicolette BorekOffice of Science, Center for Tobacco Products, U.S. Food and Drug Administration, Silver Spring, MD, USA.
Ying Deng-BryantOffice of Science, Center for Tobacco Products, U.S. Food and Drug Administration, Silver Spring, MD, USA.
Elena MishinaOffice of Science, Center for Tobacco Products, U.S. Food and Drug Administration, Silver Spring, MD, USA.
Charles LawrenceBehavioral Health and Health Policy, Westat, Rockville, MD, USA.ORCID 0000-0002-0350-7259
Andrew HylandRoswell Park Comprehensive Cancer Center, Roswell Park Cancer Institute , Buffalo, NY, USA.
Stephen S HechtMasonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0001-7228-1356
Kevin P ConwayDivision of Epidemiology, Services and Prevention Research, National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, USA.
James L PirkleDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Lanqing WangDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.ORCID 0000-0001-6620-7096
Centers for Disease Control and Prevention · USUnited States Food and Drug Administration · USNational Institutes of Health · USRoswell Park Comprehensive Cancer Center · USUniversity of Minnesota Medical Center · USWestat (United States) · US

Funding

FDA HHSNIDA NIH HHS HHSN271201100027CNIDA NIH HHS HHSN271201600001C
6 · The paper itself

Abstract

introductionThe Population Assessment of Tobacco and Health (PATH) Study is a nationally representative cohort of tobacco product users and nonusers. The study's main purpose is to obtain longitudinal epidemiologic data on tobacco use and exposure among the US population. AIMS AND

methodsNicotine biomarkers-cotinine (COT) and trans-3'-hydroxycotinine (HCT)-were measured in blood samples collected from adult daily tobacco users and nonusers during Wave 1 of the PATH Study (2013-2014; n = 5012; one sample per participant). Participants' tobacco product use and exposure to secondhand smoke were categorized based on questionnaire responses. Nonusers were subdivided into never users and recent former users. Daily tobacco users were classified into seven tobacco product use categories: exclusive users of cigarette, smokeless tobacco, electronic cigarette, cigar, pipe, and hookah, as well as polyusers. We calculated sample-weighted geometric mean (GM) concentrations of cotinine, HCT, and the nicotine metabolite ratio (NMR) and evaluated their associations with tobacco use with adjustment for potential confounders.

resultsThe GMs (95% confidence intervals) of COT and HCT concentrations for daily tobacco users were 196 (184 to 208) and 72.5 (67.8 to 77.4) ng/mL, and for nonusers they were 0.033 (0.028 to 0.037) and 0.021 (0.018 to 0.023) ng/mL. Exclusive smokeless tobacco users had the highest COT concentrations of all user groups examined. The GM NMR in daily users was 0.339 (95% confidence interval: 0.330 to 0.350).

conclusionsThese nationally representative estimates of serum nicotine biomarkers could be the basis for reference ranges characterizing nicotine exposure for daily tobacco users and nonusers in the US adult population. IMPLICATIONS: This report summarizes the serum nicotine biomarker measurements in Wave 1 of the PATH Study. We are reporting the first estimates of HCT in serum for daily tobacco users and nonusers in the noninstitutionalized, civilian US adult population; the first nationally representative serum COT estimates for daily exclusive users of different tobacco products and daily polyusers; and the first nationally representative estimate of the serum NMR in daily tobacco users by age, race/ethnicity, and sex.

Indexed as

Electronic Nicotine Delivery SystemsTobacco Use DisorderAdultBiomarkersCotinineHumansNicotineBiomarkersCotininehydroxycotinineNicotine

Identifiers

PMID34897512
PMCPMC8962725
OpenAlexW4200118850

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.