Evidence map›Paper›PMID 34897281›Full record

ArticlePediatric research2023

Impact of hydroxyurea on lymphocyte subsets in children with sickle cell anemia.

Khalid I Elsayh, Khaled Saad, Helal F Hetta, Mervat A M Youssef, Mostafa M Embaby, Ismail L Mohamed, Safwat M Abdel-Aziz, Zeinab Albadry M Zahran, Amira Elhoufey, Aliaa M A Ghandour and 1 more

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In one paragraph

Article in Pediatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 2 countries.

Khalid I ElsayhDepartment of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt.
Khaled SaadDepartment of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt. khaled.ali@med.au.edu.eg.
Helal F HettaDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Mervat A M YoussefDepartment of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt.
Mostafa M EmbabyDepartment of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt.
Ismail L MohamedDepartment of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt.
Safwat M Abdel-AzizDepartment of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt.
Zeinab Albadry M ZahranDepartment of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Amira ElhoufeyDepartment of Community Health Nursing, Faculty of Nursing, Assiut University, Assiut, Egypt.
Aliaa M A GhandourDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Asmaa M ZahranDepartment of Clinical Pathology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.
Assiut University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHydroxyurea (HU) has beneficial effects in the management of sickle cell anemia (SCA), but there is a paucity of data on the effect of HU on immune cells in SCA. Herein we aimed to evaluate the effect of HU on immune profiles of Egyptian children with SCA.

methodsThis was a controlled prospective cohort study conducted in 30 children with SCA and 30 healthy age-matched controls. Flow cytometry was used to evaluate lymphocyte profiles, including CD8+ T, CD19+ B, CD3+, CD4+, natural killer (NK), NK T, T helper 1 (Th1), Th2, T cytotoxic (Tc1), and Tc2 cells, prior to and after 1 year of treatment with HU.

resultsHU treatment led to significant increases in hemoglobin (Hb), red blood cell, and hematocrit counts and a significant decrease in the percentage of sickle Hb, with subsequent improvement in SCA complications. Compared with baseline values, CD3+, CD4+, Th1, and CD8+ T cells were significantly increased, while NK, Th2, and Tc2 cells were significantly decreased, with a resulting increase in the Th1/Th2 and Tc1/Tc2 ratios.

conclusionsHU has the beneficial effect of restoring the abnormally elevated immune parameters in children with SCA. IMPACT: Hydroxyurea treatment restores the abnormal immune parameters in children with sickle cell anemia. HU treatment led to significantly increased CD3+, CD4+, Th1, and CD8+ T cells, while NK, Th2, and Tc2 cells were significantly decreased, with a resulting increase in the Th1/Th2 and Tc1/Tc2 ratios. Our study showed the impact of HU therapy on immune parameters in children with SCA.

Indexed as

Anemia, Sickle CellHydroxyureaChildHumansProspective StudiesTh1 CellsTh2 CellsT-Lymphocyte SubsetsHydroxyurea

Identifiers

PMID34897281
OpenAlexW4200342894

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.