Evidence map›Paper›PMID 34897155›Full record

ArticleInternal medicine (Tokyo, Japan)2022

Refractory Longitudinally Extensive Transverse Myelitis after Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination in a Japanese Man.

Noriyuki Miyaue, Akira Yoshida, Yuki Yamanishi, Satoshi Tada, Rina Ando, Yuko Hosokawa, Hayato Yabe, Masahiro Nagai

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
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  5. Article
  6. Article
  7. Review
  8. Article
  9. Post-COVID-19 Vaccination CNS Magnetic Resonance Imaging Findings: A Systematic Review.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2023
    Review
  10. Review
  11. SARS-CoV-2 vaccinations complicated by transverse myelitis.Human vaccines & immunotherapeutics · 2022
    Article
  12. Article
  13. Article
  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Noriyuki MiyaueDepartment of Clinical Pharmacology and Therapeutics, Ehime University Graduate School of Medicine, Japan.
Akira YoshidaDepartment of Clinical Pharmacology and Therapeutics, Ehime University Graduate School of Medicine, Japan.
Yuki YamanishiDepartment of Clinical Pharmacology and Therapeutics, Ehime University Graduate School of Medicine, Japan.
Satoshi TadaDepartment of Clinical Pharmacology and Therapeutics, Ehime University Graduate School of Medicine, Japan.
Rina AndoDepartment of Clinical Pharmacology and Therapeutics, Ehime University Graduate School of Medicine, Japan.
Yuko HosokawaDepartment of Neurology, Saiseikai Matsuyama Hospital, Japan.
Hayato YabeDepartment of Neurology, Saiseikai Matsuyama Hospital, Japan.
Masahiro NagaiDepartment of Clinical Pharmacology and Therapeutics, Ehime University Graduate School of Medicine, Japan.
Ehime University · JPSaiseikai Matsuyama Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed and administered worldwide. There have been reports of neurological adverse events following immunization (AEFIs). We herein report a case of refractory longitudinally extensive transverse myelitis in a 75-year-old Japanese man following the first dose of the BNT162b2 vaccine. The patient developed total sensory loss below the umbilicus and complete paralysis in both legs. Although he was treated with steroid therapy and plasma exchange, his recovery was limited, and severe sequelae remained. Further studies, including large epidemiological studies, are required to understand the association between SARS-CoV-2 vaccines and neurological AEFI.

Indexed as

COVID-19Myelitis, TransverseAgedBNT162 VaccineCOVID-19 VaccinesHumansJapanMaleSARS-CoV-2VaccinationBNT162 VaccineCOVID-19 Vaccinesadverse event following immunizationCOVID-19longitudinally extensive transverse myelitisSARS-CoV-2transverse myelitisvaccine

Identifiers

PMID34897155
PMCPMC8943383
OpenAlexW4200613869

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.