Evidence map›Paper›PMID 34896961›Full record

ArticleJournal of adolescence2021

"Because all mothers is not the same": The development and implementation of an in loco parentis informed consent procedure to enroll adolescent girls and young women to participate in HIV research.

Courtney Peasant Bonner, Celia B Fisher, Tara Carney, Felicia A Browne, Margaret W Gichane, Brittni N Howard, Leslie Turner, Wendee M Wechsberg

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In one paragraph

Article in Journal of adolescence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02974998 (Expanding HIV Testing and Prevention to Reach Vulnerable Young Women), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02974998 nacompletednot on this map

Expanding HIV Testing and Prevention to Reach Vulnerable Young Women

TypeinterventionalSponsorRTI InternationalRan2016 to 2019Enrolled500ConditionsCondomless Sex, Human Immunodeficiency Virus (HIV), Sexually Transmitted Infections (STIs), Alcohol and Drug UseArmsYoung Women's Health CoOp (YWHC), Standard HTC
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Courtney Peasant BonnerSubstance Use, Gender, and Applied Research Program, RTI International, Atlanta, GA, USA; Department of Maternal and Child Health, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA. Electronic address: cpbonner@rti.org.
Celia B FisherCenter for Ethics Education, Fordham University, USA.
Tara CarneyAlcohol, Tobacco and Other Drug Research Unit, South African Medical Research Council, Cape Town, South Africa.
Felicia A BrowneDepartment of Maternal and Child Health, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA; Substance Use, Gender, and Applied Research Program, RTI International, Research Triangle Park, NC, USA.
Margaret W GichaneSubstance Use, Gender, and Applied Research Program, RTI International, Research Triangle Park, NC, USA.
Brittni N HowardSubstance Use, Gender, and Applied Research Program, RTI International, Research Triangle Park, NC, USA.
Leslie TurnerSubstance Use, Gender, and Applied Research Program, RTI International, Research Triangle Park, NC, USA.
Wendee M WechsbergDepartment of Maternal and Child Health, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA; Substance Use, Gender, and Applied Research Program, RTI International, Research Triangle Park, NC, USA; Department of Psychology, North Carolina State University, Raleigh, NC, USA; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA.

Funding

Training Program in HIV Prevention Research EthicsR25DA031608 · NIDA · FORDHAM UNIVERSITY · PI FISHER, CELIA B · 2011 to 2025
$4.9M
Expanding HIV Testing and Prevention to Reach Vulnerable Young WomenR01DA041227 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI WECHSBERG, WENDEE M · 2015 to 2019
$2.0M
NIDA NIH HHS R01 DA041227NIDA NIH HHS R25 DA031608
6 · The paper itself

Abstract

introductionSouth Africa has one of the highest incidences of HIV among adolescent girls and young women (AGW), ages 15-24, and recent research has focused on developing interventions for HIV prevention. However, the South African National Health Act requires those under 18 years of age to obtain a guardian's permission to participate in research. Limiting research enrolment to AGYW who can obtain guardian consent may lead to non-representative findings. Therefore, innovative, inclusive consent approaches that protect AGYW from the risks of research are needed.

methodsThis report details the development and implementation of an approach called the in loco parentis (in place of parent) consent procedure. In loco parentis consent provides a vehicle for adolescent participation that protects adolescents from potential social harms. The in loco parentis consent procedure does not seek to obtain independent minor consent but seeks to obtain permission for the minor to participate in research from a trusted adult who is not a minor's parent or legal guardian. This report also qualitatively explores the experiences of 31 AGYW who were recruited into a behavioral HIV prevention study using this method.

resultsFindings suggest that the in loco parentis consent procedure is a feasible and acceptable method to inclusively AGYW in HIV research.

conclusionsThe in loco parentis procedure may provide a more inclusive strategy to recruit AGYW for HIV research to increase the generalizability of findings.

Indexed as

HIV InfectionsMothersAdolescentAdultBlack PeopleFemaleHumansInformed ConsentParentsYoung AdultAssentConsentEthicsHIVRegulationsSubstance use

Identifiers

PMID34896961
PMCPMC10916742

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.