ReviewEnvironment international2022
Understanding the dynamics of physiological changes, protein expression, and PFAS in wildlife.
Review in Environment international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.
- Spatial-temporal patterns of perfluoroalkyl substances in the biota of the Laurentian Great Lakes: A meta-analysis.Journal of environmental qualityPooled it
- Bioaccumulation dynamics of perfluorooctane sulfonic acid (PFOS) and a binary mixture of PFOS and perfluorohexane sulfonic acid (PFHxS) in northern bobwhite (Colinus virginianus): a mini review.Ecotoxicology (London, England) · 2026Review
- Differences in PFAS exposure between Pacific pinnipeds: The Galapagos (Zalophus wollebaeki) and California (Zalophus californianus) sea lions.Marine pollution bulletin · 2026Article
- The Thyroid Under Pressure: Heavy Metals, Endocrine Disruptors and Translational Insights into Carcinogenesis and Thyroid Dysfunctions.International journal of molecular sciences · 2026Review
- A molecular and cellular understanding of PFDA-exposure-associated outcomes on biological assemblies.Environmental research · 2026Article
- Home-Produced Eggs as Indicators of PFAS Contamination in Food Following a Fire at a Plastic Recycling Plant.Foods (Basel, Switzerland) · 2026Article
- Development of a QSAR model for predicting PPARα activation by PFAS based on human in vitro data of a comprehensive panel of legacy and novel PFAS.Archives of toxicology · 2026Article
- An Ecosystem-Scale Model of PFAS Dynamics in Stream-to-Riparian Food Webs.Environmental science & technology · 2026Article
- Comment on Petre et al. Tissue Bioconcentration Pattern and Biotransformation of Per-Fluorooctanoic Acid (PFOA) inFoods (Basel, Switzerland) · 2026Article
- Temperature Modulates PFAS Accumulation and Effects on Metabolic Performance in Sheepshead Minnows.Environmental science & technology · 2026Article
- The influence of temperature and conductivity on metabolism and Per- and Polyfluoroalkyl Substance (PFAS) bioconcentration in Bluegill (Lepomis macrochirus).Ecotoxicology (London, England) · 2026Article
- Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Maternal Thyroid Function during Pregnancy in a Cohort with High Familial Likelihood of Autism Spectrum Disorder.Environmental science & technology · 2025Article
- Perfluorooctanoic acid, perfluorobutanoic acid, and undecafluoro-2-methyl-3-oxahexanoic acid disrupt neurotransmitter release and cholinesterase activity.Chemosphere · 2025Article
- Interaction of Perfluorooctanoate and Perfluorohexanoate withLangmuir : the ACS journal of surfaces and colloids · 2025Article
- Review
- Identifying proteomic prognostic markers for Alzheimer's disease with survival machine learning: The Framingham Heart Study.The journal of prevention of Alzheimer's disease · 2025Article
- Prenatal exposure to endocrine-disrupting chemicals and childhood atopic dermatitis: epidemiological evidence.Frontiers in microbiology · 2025Review
- Cross-cutting studies of per- and polyfluorinated alkyl substances (PFAS) in Arctic wildlife and humans.The Science of the total environment · 2024Review
- Per- and polyfluoroalkyl substances alter innate immune function: evidence and data gaps.Journal of immunotoxicology · 2024Review
- Considerations and challenges in support of science and communication of fish consumption advisories for per- and polyfluoroalkyl substances.Integrated environmental assessment and management · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
Per- and polyfluoroalkyl substances (PFAS) accumulation and elimination in both wildlife and humans is largely attributed to PFAS interactions with proteins, including but not limited to organic anion transporters (OATs), fatty acid binding proteins (FABPs), and serum proteins such as albumin. In wildlife, changes in the biotic and abiotic environment (e.g. salinity, temperature, reproductive stage, and health status) often lead to dynamic and responsive physiological changes that alter the prevalence and location of many proteins, including PFAS-related proteins. Therefore, we hypothesize that if key PFAS-related proteins are impacted as a result of environmentally induced as well as biologically programmed physiological changes (e.g. reproduction), then PFAS that associate with those proteins will also be impacted. Changes in tissue distribution across tissues of PFAS due to these dynamics may have implications for wildlife studies where these chemicals are measured in biological matrices (e.g., serum, feathers, eggs). For example, failure to account for factors contributing to PFAS variability in a tissue may result in exposure misclassification as measured concentrations may not reflect average exposure levels. The goal of this review is to share general information with the PFAS research community on what biotic and abiotic changes might be important to consider when designing and interpreting a biomonitoring or an ecotoxicity based wildlife study. This review will also draw on parallels from the epidemiological discipline to improve study design in wildlife research. Overall, understanding these connections between biotic and abiotic environments, dynamic protein levels, PFAS levels measured in wildlife, and epidemiology serves to strengthen study design and study interpretation and thus strengthen conclusions derived from wildlife studies for years to come.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.