Evidence map›Paper›PMID 34896650›Full record

ReviewAutoimmunity reviews2022

Autoantibodies and SARS-CoV2 infection: The spectrum from association to clinical implication: Report of the 15th Dresden Symposium on Autoantibodies.

Jan Damoiseaux, Arad Dotan, Marvin J Fritzler, Dimitrios P Bogdanos, Pier Luigi Meroni, Dirk Roggenbuck, Michel Goldman, Nils Landegren, Paul Bastard, Yehuda Shoenfeld and 1 more

Open access · hybridAbstract readReview
In one paragraph

Review in Autoimmunity reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 2 pooled it
6.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 85 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 10 institutions in 9 countries.

Jan DamoiseauxCentral Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, the Netherlands. Electronic address: jan.damoiseaux@mumc.nl.
Arad DotanZabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Marvin J FritzlerDepartment of Medicine, Cumming School of Medicine, Calgary, Alberta, Canada.
Dimitrios P BogdanosDepartment of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Pier Luigi MeroniIRCCS Istituto Auxologico Italiano, Milan, Italy.
Dirk RoggenbuckFaculty Environment and Natural Sciences and Faculty of Health Sciences Brandenburg, Brandenburg University of Technology Cottbus-Senftenberg, Senftenberg, Germany.
Michel GoldmanInstitute for interdisciplinary innovation in healthcare, Université libre de Bruxelles, Belgium.
Nils LandegrenDepartment of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden; Department of Medicine (Solna), Centre for Molecular Medicine, Karolinska Institute, Stockholm, Sweden.
Paul BastardLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France; Imagine Institute, University of Paris, Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Yehuda ShoenfeldZabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Ariel University, Israel; Laboratory of the Mosaics of Autoimmunity, Saint Peterburg University, 199034, Russia.
Karsten ConradInstitute of Immunology, Technical University of Dresden, Dresden, Germany.
Brandenburg University of Technology Cottbus-Senftenberg · DEIstituti di Ricovero e Cura a Carattere Scientifico · ITMaastricht University · NLRockefeller University · USSheba Medical Center · ILTel Aviv University · ILTU Dresden · DEUniversity of Calgary · CAUniversity of Thessaly · GRUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The relation between infections and autoimmune diseases has been extensively investigated. Multiple studies suggest a causal relation between these two entities with molecular mimicry, hyperstimulation and dysregulation of the immune system as plausible mechanisms. The recent pandemic with a new virus, i.e., SARS-CoV-2, has resulted in numerous studies addressing the potential of this virus to induce autoimmunity and, eventually, autoimmune disease. In addition, it has also revealed that pre-existing auto-immunity (auto-Abs neutralizing type I IFNs) could cause life-threatening disease. Therefore, the topic of the 15th Dresden Symposium on Autoantibodies was focused on autoimmunity in the SARS-CoV-2 era. This report is a collection and distillation of the topics presented at this meeting.

Indexed as

COVID-19RNA, ViralAutoantibodiesAutoimmunityHumansSARS-CoV-2AutoantibodiesRNA, ViralAnti-IFNαAntiphospholipid syndromeAutoantibodiesAutoimmunityCOVID-19MIS-CMolecular mimicrySARS-CoV-2

Identifiers

PMID34896650
PMCPMC8656211
OpenAlexW4200509336

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.