Evidence map›Paper›PMID 34896631›Full record

ArticleActa biomaterialia2022

Hybrid nanocoatings of self-assembled organic-inorganic amphiphiles for prevention of implant infections.

Zhou Ye, Ting Sang, Kun Li, Nicholas G Fischer, Isha Mutreja, Constanza Echeverría, Dhiraj Kumar, Zhen Tang, Conrado Aparicio

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biomaterialia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  16. Overcoming Methicillin-ResistanceAntibiotics (Basel, Switzerland) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhou YeMDRCBB, Minnesota Dental Research Center for Biomaterials and Biomechanics, University of Minnesota, Minneapolis, MN 55455, United States. Electronic address: zye2@nd.edu.
Ting SangThe Affiliated Stomatological Hospital of Nanchang University & The Key Laboratory of Oral Biomedicine, Nanchang, Jiangxi Province 330006, China.
Kun LiThe Affiliated Stomatological Hospital of Nanchang University & The Key Laboratory of Oral Biomedicine, Nanchang, Jiangxi Province 330006, China.
Nicholas G FischerMDRCBB, Minnesota Dental Research Center for Biomaterials and Biomechanics, University of Minnesota, Minneapolis, MN 55455, United States.
Isha MutrejaMDRCBB, Minnesota Dental Research Center for Biomaterials and Biomechanics, University of Minnesota, Minneapolis, MN 55455, United States.
Constanza EcheverríaCariology Unit, Department of Oral Rehabilitation, University of Talca, Talca 3460000, Chile.
Dhiraj KumarMDRCBB, Minnesota Dental Research Center for Biomaterials and Biomechanics, University of Minnesota, Minneapolis, MN 55455, United States.
Zhen TangThe Affiliated Stomatological Hospital of Nanchang University & The Key Laboratory of Oral Biomedicine, Nanchang, Jiangxi Province 330006, China. Electronic address: tangzhen307@aliyun.com.
Conrado AparicioMDRCBB, Minnesota Dental Research Center for Biomaterials and Biomechanics, University of Minnesota, Minneapolis, MN 55455, United States. Electronic address: cjaparicio@uic.es.

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
Minnesota Craniofacial Research Training ProgramT90DE022732 · NIDCR · UNIVERSITY OF MINNESOTA · PI MANSKY, KIM CARPENTER · 2012 to 2023
$4.9M
A novel peptide-enhanced class-V dental restorative system with a 3-tier fortificationR01DE026117 · NIDCR · UNIVERSITY OF MINNESOTA · PI APARICIO, CONRADO · 2016 to 2018
$1.1M
NCATS NIH HHS UL1 TR002494NIDCR NIH HHS R01 DE026117NIDCR NIH HHS T90 DE022732
6 · The paper itself

Abstract

Antimicrobial coatings are one of the most promising strategies to prevent bacterial infections in orthopedic and dental implants. Combining antimicrobial agents with different antimicrobial mechanisms might have synergistic effects and be more potent. Others have shown that nanocomposites of silver nanoparticles (AgNPs) decorated with antimicrobial peptides (AMPs) show increased potency as free agents in solution. However, similar nanocomposites have not been explored to coat biomaterials through cooperative weak electrostatic attraction forces between AMP, AgNPs and substrates in need of protection against infection. In this work, we synthesized self-assembled antimicrobial amphiphiles of an AMP, GL13K. Then, we decorated the AMP nanostructures with AgNPs, which were finally used to coat etched Ti (eTi) surfaces. The strong hydrogen bonding between the AMP amphiphiles and the polar eTi yielded a robust and stable coating. When compared to single AgNP or single AMP coatings, our hybrid nanocoatings had notably higher in vitro antimicrobial potency against multiple bacteria strains related to implant infection. The hybrid coating also showed relevant antimicrobial activity in an in vivo subcutaneous infection model in rats. This work advances the application of AgNP/AMP nanocomposites as effective coatings for prevention of implant infections. STATEMENT OF SIGNIFICANCE: High morbidity, mortality and elevated costs are associated with orthopedic and dental implant infections. Conventional antibiotic treatment is ineffective due to barrier-like extracellular polymeric substances in biofilms and the increasing threat from antibiotic resistance. Antimicrobial coatings are one of the most promising strategies, but the performance is usually unsatisfactory, especially when tested in vivo. Here, we present a hybrid nanocoating with different modes of action to prevent implant infections using self-assembled antimicrobial peptide (AMP) amphiphiles decorated with silver nanoparticles (AgNPs). When compared to single AgNP or AMP coatings, our hybrid nanocoatings showed significant increases in antimicrobial potency against multiple implant infection-related bacterial strains in vitro and in an in vivo rat subcutaneous infection model.

Indexed as

Coated Materials, BiocompatibleMetal NanoparticlesAnimalsAnti-Bacterial AgentsBiofilmsRatsSilverAnti-Bacterial AgentsCoated Materials, BiocompatibleSilverAntimicrobial coatingsAntimicrobial peptidesHybrid nanostructuresPeri-implant infectionsSilver nanoparticle

Identifiers

PMID34896631
PMCPMC8828705

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.