ArticleNeuroImage2022
Functional differentiation in the language network revealed by lesion-symptom mapping.
Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- The Neurofunctional Correlates of Morphosyntactic and Thematic Impairments in Aphasia: A Systematic Review and Meta-analysis.Neuropsychology review · 2025Pooled it
- Fixel-Based White Matter Correlates of Sentence Comprehension in Post-Stroke Aphasia.Brain sciences · 2025Article
- Neural effect of childhood maltreatment on neurovascular coupling in adolescent depression.European child & adolescent psychiatry · 2025Article
- A Functional Magnetic Resonance Imaging Study of Phrase Structure and Subject Island Violations.Journal of cognitive neuroscience · 2025Article
- Temporoparietal brain structures support sentence processing across the adult lifespan.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Distinct neural correlates of morphosyntactic and thematic comprehension processes in aphasia.Brain communications · 2025Article
- Differences in motor network reorganization between patients with good and poor upper extremity impairment outcomes after stroke.Brain imaging and behavior · 2024Article
- An fMRI study of phrase structure and subject island violations.bioRxiv : the preprint server for biology · 2024Article
- Lesion-symptom Mapping of Acceptability Judgments in Chronic Poststroke Aphasia Reveals the Neurobiological Underpinnings of Receptive Syntax.Journal of cognitive neuroscience · 2024Article
- Conversational production and comprehension: fMRI-evidence reminiscent of but deviant from the classical Broca-Wernicke model.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Neural basis of speech and grammar symptoms in non-fluent variant primary progressive aphasia spectrum.Brain : a journal of neurology · 2024Article
- Mapping sentence comprehension and syntactic complexity: evidence from 131 stroke survivors.Brain communications · 2024Article
- Verbal working memory and syntactic comprehension segregate into the dorsal and ventral streams, respectively.Brain communications · 2024Article
- Causal evidence for a coordinated temporal interplay within the language network.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Grammatical Parallelism in Aphasia: A Lesion-Symptom Mapping Study.Neurobiology of language (Cambridge, Mass.) · 2023Article
- Lexico-semantics obscures lexical syntax.Frontiers in language sciences · 2023Article
- Article
- A precise language network revealed by the independent component-based lesion mapping in post-stroke aphasia.Frontiers in neurology · 2022Article
- Syntactic processing engages the semantic control network.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Theories of language organization in the brain commonly posit that different regions underlie distinct linguistic mechanisms. However, such theories have been criticized on the grounds that many neuroimaging studies of language processing find similar effects across regions. Moreover, condition by region interaction effects, which provide the strongest evidence of functional differentiation between regions, have rarely been offered in support of these theories. Here we address this by using lesion-symptom mapping in three large, partially-overlapping groups of aphasia patients with left hemisphere brain damage due to stroke (N = 121, N = 92, N = 218). We identified multiple measure by region interaction effects, associating damage to the posterior middle temporal gyrus with syntactic comprehension deficits, damage to posterior inferior frontal gyrus with expressive agrammatism, and damage to inferior angular gyrus with semantic category word fluency deficits. Our results are inconsistent with recent hypotheses that regions of the language network are undifferentiated with respect to high-level linguistic processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.