ArticleBiophysical journal2022
Red blood cell shape transitions and dynamics in time-dependent capillary flows.
Article in Biophysical journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- Article
- An AI-enabled tool for quantifying overlapping red blood cell sickling dynamics in microfluidic assays.Lab on a chip · 2026Article
- Microfluidic capillary transit velocity as a functional measure for sickle cell disease andLab on a chip · 2026Article
- Gas-Solid Phase Separation of Active Brownian Particles Under Confinement of Hard Walls.Nanomaterials (Basel, Switzerland) · 2025Article
- Pathophysiological Associations and Measurement Techniques of Red Blood Cell Deformability.Biosensors · 2025Review
- Viscosity and density measurements on the cytosol of human red blood cells.Biophysical journal · 2025Article
- Article
- Buckling of red blood cell membrane in narrow capillaries induces excessive wall shear stress.Biophysical journal · 2025Article
- Review
- Deformability of Heterogeneous Red Blood Cells in Aging and Related Pathologies.Aging and disease · 2024Review
- Digital in-line holographic microscopy for label-free identification and tracking of biological cells.Military Medical Research · 2024Review
- Confinement effect on the microcapillary flow and shape of red blood cells.Biomicrofluidics · 2024Article
- Marginated aberrant red blood cells induce pathologic vascular stress fluctuations in a computational model of hematologic disorders.Science advances · 2023Article
- "Live" Nanomaterials Process Biomimetic Recognition and Assembly In Vivo.Small science · 2023Article
- [Influence of pH value on tube formation of human dermal microvascular endothelial cells and its molecular mechanism].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2023Article
- Effects of membrane viscoelasticity on the red blood cell dynamics in a microcapillary.Biophysical journal · 2023Article
- Big Data in Transfusion Medicine and Artificial Intelligence Analysis for Red Blood Cell Quality Control.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2023Review
- Article
- Influence of storage and buffer composition on the mechanical behavior of flowing red blood cells.Biophysical journal · 2023Article
- Cross-talk between red blood cells and plasma influences blood flow and omics phenotypes in severe COVID-19.eLife · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dynamics of single red blood cells (RBCs) determine microvascular blood flow by adapting their shape to the flow conditions in the narrow vessels. In this study, we explore the dynamics and shape transitions of RBCs on the cellular scale under confined and unsteady flow conditions using a combination of microfluidic experiments and numerical simulations. Tracking RBCs in a comoving frame in time-dependent flows reveals that the mean transition time from the symmetric croissant to the off-centered, nonsymmetric slipper shape is significantly faster than the opposite shape transition, which exhibits pronounced cell rotations. Complementary simulations indicate that these dynamics depend on the orientation of the RBC membrane in the channel during the time-dependent flow. Moreover, we show how the tank-treading movement of slipper-shaped RBCs in combination with the narrow channel leads to oscillations of the cell's center of mass. The frequency of these oscillations depends on the cell velocity, the viscosity of the surrounding fluid, and the cytosol viscosity. These results provide a potential framework to identify and study pathological changes in RBC properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.