Evidence map›Paper›PMID 34896295›Full record

ArticleContemporary clinical trials2022

The protocol of the Application of Economics & Social psychology to improve Opioid Prescribing Safety trial 2 (AESOPS-2): Availability of opioid harm.

Marcella A Kelley, Stephen D Persell, Jeffrey A Linder, Mark W Friedberg, Daniella Meeker, Craig R Fox, Noah J Goldstein, Tara K Knight, Dina Zein, Mark D Sullivan and 1 more

Registry-linked trialOpen access · greenAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04758637 (Application of Economics & Social Psychology to Improve Opioid Prescribing Safety Trial 2), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 73% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04758637 nacompletednot on this mapstarted 2023, after this paper: background citation

Application of Economics & Social Psychology to Improve Opioid Prescribing Safety Trial 2 (AESOPS-2): Availability of Opioid Harm

TypeinterventionalSponsorUniversity of Southern CaliforniaRan2023 to 2024Enrolled61ConditionsOpioid AbuseArmsOverdose Notification
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Marcella A KelleySchaeffer Center for Health Economics and Policy, University of Southern California, Los Angeles, CA, United States of America; School of Pharmacy, University of Southern California, Los Angeles, CA, United States of America.
Stephen D PersellDivision of General Internal Medicine and Geriatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America.
Jeffrey A LinderDivision of General Internal Medicine and Geriatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America.
Mark W FriedbergBlue Cross & Blue Shield of Massachusetts, Boston, MA, United States of America.
Daniella MeekerSchaeffer Center for Health Economics and Policy, University of Southern California, Los Angeles, CA, United States of America; Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America.
Craig R FoxAnderson School of Management, University of California at Los Angeles, Los Angeles, CA, United States of America.
Noah J GoldsteinAnderson School of Management, University of California at Los Angeles, Los Angeles, CA, United States of America.
Tara K KnightSchaeffer Center for Health Economics and Policy, University of Southern California, Los Angeles, CA, United States of America; Sol Price School of Public Policy, University of Southern California, Los Angeles, CA, United States of America.
Dina ZeinSchaeffer Center for Health Economics and Policy, University of Southern California, Los Angeles, CA, United States of America.
Mark D SullivanSchool of Medicine, University of Washington, Seattle, WA, United States of America.
Jason N DoctorSchaeffer Center for Health Economics and Policy, University of Southern California, Los Angeles, CA, United States of America; School of Pharmacy, University of Southern California, Los Angeles, CA, United States of America; Sol Price School of Public Policy, University of Southern California, Los Angeles, CA, United States of America. Electronic address: jdoctor@usc.edu.
University of Southern California · USNorthwestern University · USUniversity of California, Los Angeles · USBlue Cross Blue Shield of Massachusetts · USUniversity of Washington · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
USC-Yale Roybal Center for Behavioral Interventions in AgingP30AG024968 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JASON N. DOCTOR · 2004 to 2026
$14.7M
Use of Behavioral Economics in Repeat SARS-CoV-2 Antibody Testing in Disadvantaged CommunitiesR33AG057395 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DOCTOR, JASON N., SULLIVAN, MARK D · 2019 to 2021
$3.3M
Application of Economics & Social psychology to improve Opioid Prescribing Safety (AESOPS) TrialR21AG057395 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DOCTOR, JASON N., SULLIVAN, MARK D · 2017 to 2018
$494k
NCATS NIH HHS UL1 TR001422NIA NIH HHS P30 AG024968NIA NIH HHS R21 AG057395NIA NIH HHS R33 AG057395
6 · The paper itself

Abstract

backgroundHigh levels of opioid prescribing in the United States has resulted in an alarming trend in opioid-related harms. The objective of Trial 2 of the Application of Economics & Social psychology to improve Opioid Prescribing Safety (AESOPS-2) is to dampen the intensity and frequency of opioid prescribing in accordance with the Centers for Disease Control and Prevention recommendation to "go low and slow". We aim to accomplish this by notifying clinicians of harmful patient outcomes, which we expect to increase the mental availability of risks associated with opioid use.

methodsThe trial is multi-site. Random assignment determines if prescribers to persons who suffer an opioid overdose (fatal or nonfatal) learn of this event (intervention) or practice usual care (control). Clinicians in the intervention group receive a letter notifying them of their patient's overdose. The primary outcome is the change in clinician weekly milligram morphine equivalent (MME) prescribed in a 6-month period before and after receiving the letter. Additional outcomes are the change in the proportion of patients prescribed at least 50 daily MME and in the proportion of patients referred to medication assisted treatment. Group differences in these outcomes will be compared using an intent-to-treat difference-in-differences framework with a mixed-effects regression model to estimate clinician MME. DISCUSSION: The AESOPS-2 trial will provide new knowledge about whether increasing prescribers' awareness of patients' opioid-related overdoses leads to a reduction in opioid prescribing. Additionally, this trial may better inform how to reduce opioid use disorder and opioid overdoses by lowering population exposure to these drugs.

trial registrationClinicalTrials.gov: NCT04758637.

Indexed as

Drug OverdoseOpioid-Related DisordersAnalgesics, OpioidHumansMulticenter Studies as TopicPractice Patterns, Physicians'Psychology, SocialRandomized Controlled Trials as TopicUnited StatesAnalgesics, OpioidBehavioral economicsNudgesOpioid use disorderRandomized control trial

Identifiers

PMID34896295
PMCPMC8869359
OpenAlexW4200453506

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.