Evidence map›Paper›PMID 34896273›Full record

ArticleAcademic pediatrics

Prospective Pilot Study Evaluating SARS-CoV-2 Transmission-Limiting Measures in an On-Site School.

Shilpa G Jani, Jasmin Ma, Uma Pulendran, Julianna C Hsing, Jonathan Altamirano, Soleil Shah, Elizabeth Y Toomarian, Yvonne Maldonado, Chih-Hung Jason Wang

Open access · bronzeAbstract read
In one paragraph

Article in Academic pediatrics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Shilpa G JaniCenter for Policy, Outcomes, and Prevention, and Division of General Pediatrics (SG Jani, J Ma, U Pulendran, JC Hsing, S Shah and CJ Wang), Stanford University School of Medicine, Stanford, Calif.
Jasmin MaCenter for Policy, Outcomes, and Prevention, and Division of General Pediatrics (SG Jani, J Ma, U Pulendran, JC Hsing, S Shah and CJ Wang), Stanford University School of Medicine, Stanford, Calif.
Uma PulendranCenter for Policy, Outcomes, and Prevention, and Division of General Pediatrics (SG Jani, J Ma, U Pulendran, JC Hsing, S Shah and CJ Wang), Stanford University School of Medicine, Stanford, Calif.
Julianna C HsingCenter for Policy, Outcomes, and Prevention, and Division of General Pediatrics (SG Jani, J Ma, U Pulendran, JC Hsing, S Shah and CJ Wang), Stanford University School of Medicine, Stanford, Calif; Department of Epidemiology and Population Health (JC Hsing), Stanford University School of Medicine, Stanford, Calif.
Jonathan AltamiranoDivision of Infectious Diseases, Department of Pediatrics (Y Maldonado), Stanford University School of Medicine, Stanford, Calif.
Soleil ShahCenter for Policy, Outcomes, and Prevention, and Division of General Pediatrics (SG Jani, J Ma, U Pulendran, JC Hsing, S Shah and CJ Wang), Stanford University School of Medicine, Stanford, Calif.
Elizabeth Y ToomarianGraduate School of Education (EY Toomarian), Stanford University, Stanford, Calif; Synapse School (EY Toomarian), Menlo Park, Calif.
Yvonne MaldonadoDivision of Infectious Diseases, Department of Pediatrics (Y Maldonado), Stanford University School of Medicine, Stanford, Calif.
Chih-Hung Jason WangCenter for Policy, Outcomes, and Prevention, and Division of General Pediatrics (SG Jani, J Ma, U Pulendran, JC Hsing, S Shah and CJ Wang), Stanford University School of Medicine, Stanford, Calif; Center for Health Policy, Freeman-Spogli Institute for International Studies (CJ Wang), Stanford University, Stanford, Calif; Department of Health Policy (CJ Wang), Stanford University School of Medicine, Stanford, Calif. Electronic address: cjwang1@stanford.edu.
Stanford University · USStanford Medicine · USSynapse Biomedical (United States) · US

Funding

Stanford Center for Clinical & Translational Education and Research (Spectrum)UL1TR003142 · NCATS · STANFORD UNIVERSITY · PI O'HARA, RUTH M · 2019 to 2023
$45.0M
Spectrum Stanford Center for clinical and Translational Research and EducationUL1TR001085 · NCATS · STANFORD UNIVERSITY · PI CULLEN, MARK RICHARD, GREENBERG, HARRY BERNARD · 2013 to 2017
$37.1M
NCATS NIH HHS UL1 TR001085NCATS NIH HHS UL1 TR003142
6 · The paper itself

Abstract

objectivesThe purpose of our study is to evaluate the feasibility and reliability of a comprehensive set of preventive measures in limiting secondary transmission of COVID-19 in schools.

methodsA prospective cohort study was conducted to evaluate SARS-CoV-2 transmission in an independent K-8 school in San Mateo County, California. The research was conducted between September 14, 2020 through March 22, 2021 and consisted of: 1) demographic and epidemiological questionnaires; 2) daily symptom reporting; 3) weekly RT-PCR testing; and 4) periodic on-site qualitative observations.

resultsOne hundred eighty (79%) students and 63 (74%) on-site staff/contractors were enrolled. Participants reported symptoms in 144 (<1%) daily surveys of the 19,409 collected. Among those who reported symptoms and exposures, none tested positive during the 22-week study period. Of all participants, a total of 6 tested positive for SARS-CoV-2 at least once by RT-PCR; all were asymptomatic at time of testing. No in-school transmission occurred. Mask adherence was high among all grades, and incidents of improper mask use mostly occurred during noninstruction time. Physical distancing was well-enforced during class time and snack breaks, although adherence during noninstruction time waned as the school year progressed.

conclusionsOur comprehensive, prospective study following COVID-19 transmission over 22 weeks in a K-8 school demonstrates that: 1) surveillance testing is important for detecting asymptomatic infections in schools; 2) monitoring symptoms may not be necessary and/or sufficient for COVID-19; and 3) younger children can adhere to key mitigation measures (eg, masking) which have the potential to limit transmission.

Indexed as

COVID-19SARS-CoV-2ChildHumansPilot ProjectsProspective StudiesReproducibility of ResultsSchoolsCOVID-19mitigation strategieson-site learningpreventive measuresschool reopening

Identifiers

PMID34896273
PMCPMC8651529
OpenAlexW4200147526

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.