ArticleNeurotoxicology and teratology
Transient developmental exposure to tributyltin reduces optomotor responses in larval zebrafish (Danio rerio).
Article in Neurotoxicology and teratology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
5 citing papers in PubMed, 15 citations in OpenAlex.
- Early life tributyltin exposure has long term physiological effects on the zebrafish (Danio rerio) visual system.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2026Article
- Neurotoxic Effects of Acute Tributyltin Exposure in Adult Zebrafish: Behavioral Impairments and Mechanistic Insights.Metabolites · 2026Article
- A data analysis approach for locomotor behavioral responses in developmentally exposed zebrafish.NAM journal · 2025Article
- Mutation of brain aromatase disrupts spawning behavior and reproductive health in female zebrafish.Frontiers in endocrinology · 2023Article
- The Role of Estrogen and Thyroid Hormones in Zebrafish Visual System Function.Frontiers in pharmacology · 2022Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
This study determined the effects of transient developmental exposure to tributyltin (TBT), a well-known anti-estrogenic environmental endocrine disrupting compound, on visual system development of larval zebrafish (Danio rerio). Zebrafish were exposed to either 0.2 μg/L or 20 μg/L TBT for 24 h when they were aged 24 h postfertilization (hpf), 72 hpf, or 7 days (d)pf. Immediately after exposure, larvae were transferred to system water for seven days of recovery followed by behavioral testing (startle and optomotor responses) and morphological assessment. TBT-treated larvae displayed age-dependent changes in morphology characterized by delayed/reduced growth and susceptibility to exposure. TBT exposure reduced the number of larvae displaying optomotor responses regardless of age of exposure; eye diameter was also decreased when exposure occurred at 24 hpf or 7 dpf. Startle responses were reduced only in TBT-treated larvae exposed when they were 24 hpf, suggesting transient TBT exposure during the early larval period may cause vision-specific effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.