Trial reportJournal of clinical epidemiology2022
In-depth qualitative interviews identified barriers and facilitators that influenced chief investigators' use of core outcome sets in randomised controlled trials.
Trial report in Journal of clinical epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Magnetic Resonance Imaging-Based Artificial Intelligence in Predicting Prostate Cancer Biochemical Recurrence: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2026Pooled it
- Article
- Standardised reporting framework for nutrition and growth in preterm nutrition studies: the NutriGrow Delphi study.Pediatric research · 2026Article
- Protocol for developing a core outcome set for traditional Chinese medicine in the treatment of pharyngitis.Frontiers in medicine · 2026Article
- Identifying and selecting outcome measures for the children and families domestic abuse core outcome set.Frontiers in sociology · 2026Article
- Article
- Uptake of core outcome sets in paediatric clinical trials: a protocol.BMJ paediatrics open · 2025Article
- Assessing the uptake of infertility core outcome set in IVF randomized controlled trials.Human reproduction (Oxford, England) · 2025Article
- Identification and Assessment of Outcome Measurement Instruments in Cauda Equina Syndrome: A Systematic Review.Global spine journal · 2024Article
- Indifferent minds, broken system: a critical examination of mental health care provision for Spain's incarcerated population with serious mental illnesses.Frontiers in psychiatry · 2024Article
- Harmonising outcome measurement for child focused domestic abuse interventions. Reflections on the development and implementation of a core outcome set.Frontiers in psychiatry · 2024Article
- Current trends, barriers, and facilitators of use of core outcome sets in Cochrane systematic reviews: Protocol.F1000Research · 2023Article
- Awareness and experiences on core outcome set development and use amongst stakeholders from low- and middle- income countries: An online survey.PLOS global public health · 2023Article
- Using behavioural science to enhance use of core outcome sets in trials: protocol.HRB open research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
objectiveThis study aimed to investigate barriers and facilitators to core outcome set (COS) uptake in randomized controlled trials to inform the first steps in developing interventions to improve the uptake of COS. STUDY DESIGN AND
settingSemi-structured qualitative interviews with a purposive sample of United Kingdom chief investigators were audio-recorded, transcribed and analyzed thematically. Where appropriate, barriers and facilitators were mapped to components of behavior informed by the COM-B model of behavior.
resultsThirteen chief investigators were interviewed. Facilitators to uptake included: the behavior of investigators, for example, their awareness and understanding of COS; and the wider research system, for example, recommendations to use COS from funders and journals. Barriers to uptake included: the perceived characteristics of COS, for example, increasing patient burden and recommendations becoming outdated; and the COS development process, for example, not including all specialties who will use the COS.
conclusionBased on the barriers and facilitators identified, recommendations to improve COS uptake include ensuring engagement with the research community who will use the COS, involving patients in the development of COS and ensuring COS remain up to date.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.