Evidence map›Paper›PMID 34895472›Full record

ArticleStructure (London, England : 1993)2022

Slow conformational dynamics of the human A

Shushu Wei, Naveen Thakur, Arka P Ray, Beining Jin, Samuel Obeng, Christopher R McCurdy, Lance R McMahon, Hugo Gutiérrez-de-Terán, Matthew T Eddy, Rajan Lamichhane

Abstract read
In one paragraph

Article in Structure (London, England : 1993), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
  2. Activation dynamics of a water-soluble human mu-opioid receptor.The Journal of biological chemistry · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Membrane mimetic-dependence of GPCR energy landscapes.Structure (London, England : 1993) · 2024
    Article
  18. Article
  19. Single-molecule visualization of human ACommunications biology · 2023
    Article
  20. Membrane Mimetic-Dependence of GPCR Energy Landscapes.bioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shushu WeiDepartment of Biochemistry & Cellular and Molecular Biology, College of Arts and Sciences, University of Tennessee, 1311 Cumberland Avenue, Knoxville, TN 37932, USA.
Naveen ThakurDepartment of Chemistry, College of Liberal Arts and Sciences, University of Florida, 126 Sisler Hall, Gainesville, FL 32611, USA.
Arka P RayDepartment of Chemistry, College of Liberal Arts and Sciences, University of Florida, 126 Sisler Hall, Gainesville, FL 32611, USA.
Beining JinDepartment of Chemistry, College of Liberal Arts and Sciences, University of Florida, 126 Sisler Hall, Gainesville, FL 32611, USA.
Samuel ObengDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.
Christopher R McCurdyDepartment of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA; Translational Drug Development Core, Clinical and Translational Sciences Institute, University of Florida, Gainesville, FL 32610, USA.
Lance R McMahonDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.
Hugo Gutiérrez-de-TeránDepartment of Cell and Molecular Biology, Uppsala University, B.M.C., Box 596, Uppsala 751 24, Sweden.
Matthew T EddyDepartment of Chemistry, College of Liberal Arts and Sciences, University of Florida, 126 Sisler Hall, Gainesville, FL 32611, USA. Electronic address: matthew.eddy@chem.ufl.edu.
Rajan LamichhaneDepartment of Biochemistry & Cellular and Molecular Biology, College of Arts and Sciences, University of Tennessee, 1311 Cumberland Avenue, Knoxville, TN 37932, USA. Electronic address: rajan@utk.edu.

Funding

Opioid use disorders: UF Pharmacy medications discovery and developmentUH3DA048353 · NIDA · UNIVERSITY OF FLORIDA · PI MCCURDY, CHRISTOPHER R, MCMAHON, LANCE R. · 2021 to 2023
$4.5M
Opioid use disorders: UF Pharmacy medications discovery and developmentUG3DA048353 · NIDA · UNIVERSITY OF FLORIDA · PI MCCURDY, CHRISTOPHER R, MCMAHON, LANCE R. · 2019 to 2020
$3.6M
Kratom alkaloids: in vitro and in vivo pharmacological mechanismsR01DA047855 · NIDA · UNIVERSITY OF FLORIDA · PI MCCURDY, CHRISTOPHER R, MCMAHON, LANCE R. · 2019 to 2023
$3.6M
R35 Supplement - Equipment SupplementR35GM138291 · NIGMS · UNIVERSITY OF FLORIDA · PI Matthew Thomas Eddy · 2020 to 2026
$2.5M
Conformational Dynamics of G Protein-Coupled Receptors at the Single-Molecule LevelR35GM142946 · NIGMS · UNIVERSITY OF TENNESSEE KNOXVILLE · PI LAMICHHANE, RAJAN · 2021 to 2025
$2.2M
NIDA NIH HHS R01 DA047855NIDA NIH HHS UG3 DA048353NIDA NIH HHS UH3 DA048353NIGMS NIH HHS R35 GM138291NIGMS NIH HHS R35 GM142946
6 · The paper itself

Abstract

A more complete depiction of protein energy landscapes includes the identification of different function-related conformational states and the determination of the pathways connecting them. We used total internal reflection fluorescence (TIRF) imaging to investigate the conformational dynamics of the human A

Indexed as

Molecular Dynamics SimulationReceptor, Adenosine A2AHumansMolecular ConformationReceptor, Adenosine A2AA2A adenosine receptorbiophysicsconformational dynamicsG-protein-coupled receptorslipid nanodiscsmembrane proteinssingle-molecule fluorescence spectroscopyTIRF

Identifiers

PMID34895472
PMCPMC8897252

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.