Evidence map›Paper›PMID 34895314›Full record

ArticleTrials2021

Incremental Velocity Error as a New Treatment in Vestibular Rehabilitation (INVENT VPT) Trial: study protocol for a randomized controlled crossover trial.

Ann-Margret Ervin, Michael C Schubert, Americo A Migliaccio, Jamie Perin, Hamadou Coulibaly, Jennifer L Millar, Dale Roberts, Mark Shelhamer, Daniel Gold, Stephanie Beauregard and 4 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03846830 (INVENT VPT), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03846830 nacompletednot on this map

INVENT VPT: Incremental Velocity Error as a New Treatment in Vestibular Rehabilitation

TypeinterventionalSponsorJohns Hopkins UniversityRan2021 to 2025Enrolled24ConditionsMild Traumatic Brain Injury, Vestibular NeuropathyArmsIncremental Velocity Error (IVE), Traditional Vestibular Rehabilitation (VPT)
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. [Research advances in the mechanism of vestibular compensation and treatment].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Ann-Margret Ervin *Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD, 21205, USA. aervin@jhu.edu.ORCID http://orcid.org/0000-0002-8610-4403
Michael C Schubert *Johns Hopkins University School of Medicine, 601 N. Caroline Street, Baltimore, MD, 21287, USA.
Americo A MigliaccioNeuroscience Research Australia, Sydney, Australia.
Jamie PerinJohns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD, 21205, USA.
Hamadou CoulibalyJohns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD, 21205, USA.
Jennifer L MillarJohns Hopkins University School of Medicine, 601 N. Caroline Street, Baltimore, MD, 21287, USA.
Dale RobertsJohns Hopkins University School of Medicine, 1800 Orleans Street, Baltimore, MD, 21287, USA.
Mark ShelhamerJohns Hopkins University School of Medicine, 601 N. Caroline Street, Baltimore, MD, 21287, USA.
Daniel GoldJohns Hopkins University School of Medicine, 601 N. Caroline Street, Baltimore, MD, 21287, USA.
Stephanie BeauregardIntrepid Spirit Center, Fort Belvoir Community Hospital, Intrepid Pavilion, 5980 9th Street, Bldg. 1259, Fort Belvoir, VA, 22060, USA.
Robin PintoNational Military Audiology and Speech Center, Walter Reed National Military Medical Center, Building 19, Room 5600, 4954 North Palmer Rd, Bethesda, MD, 20889-5630, USA.
Douglas BrungartNational Military Audiology and Speech Center, Walter Reed National Military Medical Center, Building 19, Room 5600, 4954 North Palmer Rd, Bethesda, MD, 20889-5630, USA.
Bryan K WardJohns Hopkins University School of Medicine, 601 N. Caroline Street, Baltimore, MD, 21287, USA.
INVENT VPT Research Group
Johns Hopkins University · USWalter Reed National Military Medical Center · USAlexander T. Augusta Military Medical Center · USNeuroscience Research Australia · AU

Funding

HIGH FIELD MRI AND THE LABYRINTH: VESTIBULAR STIMULATION AND NEW IMAGING TECHNIQUESK23DC018302 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI WARD, BRYAN KEVIN · 2021 to 2025
$991k
NIDCD NIH HHS K23 DC018302U.S. Department of Defense W8lXWH-l7
6 · The paper itself

Abstract

backgroundA clinical pattern of damage to the auditory, visual, and vestibular sensorimotor systems, known as multi-sensory impairment, affects roughly 2% of the US population each year. Within the population of US military service members exposed to mild traumatic brain injury (mTBI), 15-44% will develop multi-sensory impairment following a mild traumatic brain injury. In the US civilian population, multi-sensory impairment-related symptoms are also a common sequela of damage to the vestibular system and affect ~ 300-500/100,000 population. Vestibular rehabilitation is recognized as a critical component of the management of multi-sensory impairment. Unfortunately, the current clinical practice guidelines for the delivery of vestibular rehabilitation are not evidence-based and primarily rely on expert opinion. The focus of this trial is gaze stability training, which represents the unique component of vestibular rehabilitation. The aim of the Incremental Velocity Error as a New Treatment in Vestibular Rehabilitation (INVENT VPT) trial is to assess the efficacy of a non-invasive, incremental vestibular adaptation training device for normalizing the response of the vestibulo-ocular reflex.

methodsThe INVENT VPT Trial is a multi-center randomized controlled crossover trial in which military service members with mTBI and civilian patients with vestibular hypofunction are randomized to begin traditional vestibular rehabilitation or incremental vestibular adaptation and then cross over to the alternate intervention after a prescribed washout period. Vestibulo-ocular reflex function and other functional outcomes are measured to identify the best means to improve the delivery of vestibular rehabilitation. We incorporate ecologically valid outcome measures that address the common symptoms experienced in those with vestibular pathology and multi-sensory impairment. DISCUSSION: The INVENT VPT Trial will directly impact the health care delivery of vestibular rehabilitation in patients suffering from multi-sensory impairment in three critical ways: (1) compare optimized traditional methods of vestibular rehabilitation to a novel device that is hypothesized to improve vestibulo-ocular reflex performance, (2) isolate the ideal dosing of vestibular rehabilitation considering patient burden and compliance rates, and (3) examine whether recovery of the vestibulo-ocular reflex can be predicted in participants with vestibular symptoms.

trial registrationClinicalTrials.gov NCT03846830 . Registered on 20 February 2019.

Indexed as

Vestibular DiseasesVestibular SystemAdaptation, PhysiologicalCross-Over StudiesHumansMulticenter Studies as TopicRandomized Controlled Trials as TopicReflex, Vestibulo-OcularDizzinessImbalanceIncremental vestibular adaptationService members, Traumatic brain injuryVestibular rehabilitationVestibulo-ocular reflex

Identifiers

PMID34895314
PMCPMC8666079
OpenAlexW4225433938

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.