ArticleJournal of ovarian research2021
Ovarian reserve in nigerian women with sickle cell anaemia: a cross- sectional study.
Article in Journal of ovarian research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Functional ovarian reserve in women with Sickle Cell disease: A systematic review.JBRA assisted reproduction · 2024Pooled it
- Ovarian Reserve in Women of Reproductive Age With Sickle Cell Anaemia: A Scoping Review.EJHaem · 2026Review
- Ovarian reserve and oxidative stress in sickle cell anaemia: a comparative cross-sectional study.Scientific reports · 2026Article
- Impact of sickle cell anaemia on reproductive health: a narrative review.Reproductive health · 2025Review
- Late effects of hemopoietic stem cell transplant for sickle cell disease: monitoring and management.Expert review of hematology · 2024Review
- Impact of hydroxyurea on follicle density in patients with sickle cell disease.Blood advances · 2024Article
- Sickle cell disease and infertility risks: implications for counseling and care of affected girls and women.Expert review of hematology · 2024Review
- The impact of sickle cell disease and its treatment on ovarian reserve in reproductive-aged Black women.British journal of haematology · 2024Article
- Preterm management of sickle cell crisis in a twin pregnancy with suboptimal antenatal care in a primary healthcare facility: A case report from Cameroon and literature review.Clinical case reports · 2023Article
- Detrimental effects of sickle cell disease and hydroxycarbamide on ovarian reserve but uncertain impact on fertility.Blood advances · 2023Article
- Impact of vitamin B12 on the reproductive health of women with sickle cell disease: a narrative review.Reproduction & fertility · 2023Article
- Infertility and treatment-seeking practices among females and males with sickle cell disease in the Sickle Cell Disease Implementation Consortium registry.Pediatric blood & cancer · 2023Article
- Expecting more: the case for incorporating fertility services into comprehensive sickle cell disease care.The Lancet. Haematology · 2023Review
- No crystal stair: supporting fertility care and the pursuit of pregnancy in women with sickle cell disease.Hematology. American Society of Hematology. Education Program · 2022Article
- Go the Distance: Reproductive Health Care for People with Sickle Cell Disease.Hematology/oncology clinics of North America · 2022Review
- Fertility after Curative Therapy for Sickle Cell Disease: A Comprehensive Review to Guide Care.Journal of clinical medicine · 2022Review
- Article
- Fertility preservation for pediatric patients with hemoglobinopathies: Multidisciplinary counseling needed to optimize outcomes.Frontiers in endocrinology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSickle cell disease is the most common monogenetic disorder worldwide. There have been reports of endocrine dysfunction and gonadal failure among affected individuals, especially in males. The findings on ovarian reserve and failure in women with sickle anaemia have been inconsistent. AIM AND
objectiveThe aim of this study was to determine and compare the ovarian reserve of Nigerian women with and without sickle cell anaemia attending a University Teaching Hospital. STUDY
designThis cross-sectional study was carried out at the Adult Sickle Cell Clinic and the Community Health Clinic of the Lagos University Teaching Hospital. METHODOLOGY: A total of 166 participants who met the selection criteria, were recruited for the study. The study population consisted of two groups of women matched for age: 83 women with HbSS and 83 women with HbAA. The haemoglobin phenotype of each participant was determined on alkaline electrophoresis (pH 8.4) before analysis. Serum Anti-Mullerian Hormone (AMH) was determined using Enzyme-linked immunosorbent assay (ELISA) method (Calbiotech Inc. USA, Catalog no AM448T).
resultsThe mean ± SD of serum AMH level in women with HbSS was 3.64 ± 0.65 ng/mL and was lower than that of women with HbAA 7.35 ±1.19 ng/mL (p < 0.001). Serum AMH negatively correlated with age in both study groups (HbAA and HbSS). Also, a significant negative correlation was found between serum AMH and BMI in women with HbAA.
conclusionThe study showed diminished ovarian reserve in women with HbSS when compared to age-matched women with HbAA.
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Registered trials
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