Evidence map›Paper›PMID 34895274›Full record

ArticleDiagnostic pathology2021

Down-regulation of SOCS6: an unfavorable prognostic factor for gastrointestinal stromal tumor proven by survival analysis.

Jun Ouyang, Tailai An, Yan Wang, Xiaofang Lu, Yawei Zhang, Xiaokun Wang, Xinhua Zhang, Changhua Zhang

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PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostic pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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3citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Jun Ouyang *Center of Digestive Diseases, The Seventh Affiliated Hospital, Sun Yat-sen University, Zhenyuan Road 628, Guangming District, Shenzhen, Guangdong, China.
Tailai An *Department of Hepatobiliary and Pancreatic Surgery, Shenzhen People's Hospital, Guangdong, Shenzhen, China.
Yan WangDepartment of Radiology, Shenzhen People's Hospital, Shenzhen, Guangdong, China.
Xiaofang LuDepartment of Pathology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China.
Yawei ZhangCenter of Digestive Diseases, The Seventh Affiliated Hospital, Sun Yat-sen University, Zhenyuan Road 628, Guangming District, Shenzhen, Guangdong, China.
Xiaokun WangCenter of Digestive Diseases, The Seventh Affiliated Hospital, Sun Yat-sen University, Zhenyuan Road 628, Guangming District, Shenzhen, Guangdong, China.
Xinhua ZhangDepartment of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-sen University, Zhongshan Road 58, Yuexiu District, Guangzhou, Guangdong, China. zhangxinhua@mail.sysu.edu.cn.
Changhua ZhangCenter of Digestive Diseases, The Seventh Affiliated Hospital, Sun Yat-sen University, Zhenyuan Road 628, Guangming District, Shenzhen, Guangdong, China. zhchangh@mail.sysu.edu.cn.

Funding

Sanming Project of Medicine in Shenzhen SZSM201612022 to Z. L. and Y. W.
6 · The paper itself

Abstract

backgroundMany studies reporting that down-regulation of SOCS6 plays vital roles in promoting progression of malignant tumors have been published. The present study was performed to evaluate whether SOCS6 was significantly associated with prognosis of GIST patients.

methodsImmunohistochemical staining was accomplished to evaluate the expression levels of SOCS6 among GIST patients. The impacts of SOCS6 expression on overall survival (OS) and recurrence-free survival (RFS) of GIST patients were assessed by Cox proportional hazard regression model analysis and Kaplan-Meier curve analysis.

resultsIt was demonstrated that the expression level of SOCS6 was significantly associated with tumor size (P=0.001). Then according to Kaplan-Meier curve analysis, low expression of SOCS6 was significantly correlated with worse OS and RFS of GIST patients. Ultimately, it was revealed by Cox proportional regression model analysis that low expression of SOCS6 was an independent predictive factor for OS and RFS.

conclusionsLow expression of SOCS6 was an independent prognostic factor for GIST, suggesting its potential as a novel biomarker predicting survival of GIST patients.

Indexed as

AgedBiomarkers, TumorDown-RegulationFemaleGastrointestinal NeoplasmsGastrointestinal Stromal TumorsHumansImmunohistochemistryMaleMiddle AgedNeoplasm Recurrence, LocalPredictive Value of TestsProgression-Free SurvivalRetrospective StudiesRisk AssessmentRisk FactorsBiomarkers, TumorSOCS6 protein, humanSuppressor of Cytokine Signaling ProteinsCox proportional regression model analysisGastrointestinal stromal tumorOverall survivalRecurrence-free survivalSOCS6

Identifiers

PMID34895274
PMCPMC8667422

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